Beck H I, Bjerring P, Harving H
Department of Dermatology and Venereology, Marselisborg Hospital Arhus, Denmark.
Acta Derm Venereol. 1989;69(2):162-5.
Nine patients with atopic dermatitis (AD) were clinically evaluated before and after moving to new houses with improved air exchange, low relative humidity and optimal temperature control. During a 2-year period three clinical and subjective assessments were performed each month of disease activity, and compared with changes in suspended and respirable dust particles, room temperature, air exchange rate, concentration of house-dust mites in bedrooms, and the concentration of organic solvents in the indoor air. Ten matched patients with AD, who did not move, served as a control group. The skin condition of patients moved improved significantly after moving. The indoor climate was improved on: 1) air exchange rate, 2) relative humidity, and 3) room temperature, but the amounts of house dust mites, respirable air particles and organic solvents were unchanged. The clinical and subjective improvement in AD could not be correlated to any single indoor environmental factor. The present investigation supports the current concept, that AD may be a multifactorial disease, and that the indoor climate may be a contributing factor affecting the eczema.
对9名特应性皮炎（AD）患者在搬入具有改善的空气交换、低相对湿度和最佳温度控制的新房前后进行了临床评估。在2年期间，每月对疾病活动进行三次临床和主观评估，并与悬浮和可吸入灰尘颗粒、室温、空气交换率、卧室中屋尘螨浓度以及室内空气中有机溶剂浓度的变化进行比较。10名匹配的未搬家的AD患者作为对照组。搬家后，搬家患者的皮肤状况明显改善。室内气候在以下方面得到了改善：1）空气交换率，2）相对湿度，3）室温，但屋尘螨、可吸入空气颗粒和有机溶剂的量没有变化。AD的临床和主观改善与任何单一室内环境因素均无关联。本研究支持当前的观点，即AD可能是一种多因素疾病，并且室内气候可能是影响湿疹的一个促成因素。
