Woulfe J, Beaudet A
Neuroanatomy Laboratory, Montreal Neurological Institute, Que., Canada.
Brain Res. 1989 Feb 13;479(2):402-6. doi: 10.1016/0006-8993(89)91649-1.
A light- and electron-microscopic double antigen localization technique was employed to study cellular relationships between neurotensin (NT)-containing axons and dopaminergic neurons in the substantia nigra and ventral tegmental area of the rat. Direct contacts were observed between NT-immunoreactive axon terminals and the dendrites and perikarya of neurons containing the dopamine biosynthetic enzyme, tyrosine hydroxylase (TH). NT-positive terminals were also found to contact unlabeled dendrites and neuronal somata. These results reveal an ultrastructural substrate through which endogenous NT might influence the activity of dopaminergic neurons in the ventral midbrain tegmentum.
采用光镜和电镜双抗原定位技术，研究大鼠黑质和腹侧被盖区中含神经降压素（NT）的轴突与多巴胺能神经元之间的细胞关系。观察到NT免疫反应性轴突终末与含有多巴胺生物合成酶酪氨酸羟化酶（TH）的神经元的树突和胞体之间有直接接触。还发现NT阳性终末与未标记的树突和神经元胞体接触。这些结果揭示了一种超微结构基础，内源性NT可能通过该基础影响腹侧中脑被盖区多巴胺能神经元的活动。
