可卡因诱发的阴性症状需要杏仁核外侧核中的AMPA受体转运。
Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula.
作者信息
Meye Frank J, Valentinova Kristina, Lecca Salvatore, Marion-Poll Lucile, Maroteaux Matthieu J, Musardo Stefano, Moutkine Imane, Gardoni Fabrizio, Huganir Richard L, Georges François, Mameli Manuel
机构信息
1] Institut du Fer à Moulin, Paris, France. [2] Inserm, UMR-S 839, Paris, France. [3] Université Pierre et Marie Curie, Paris, France.
DiSFeB, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano, Italy.
出版信息
Nat Neurosci. 2015 Mar;18(3):376-8. doi: 10.1038/nn.3923. Epub 2015 Feb 2.
Abstract
Addictive substances mediate positive and negative states promoting persistent drug use. However, substrates for aversive effects of drugs remain elusive. We found that, in mouse lateral habenula (LHb) neurons targeting the rostromedial tegmental nucleus, cocaine enhanced glutamatergic transmission, reduced K(+) currents and increased excitability. GluA1 trafficking in LHb was instrumental for these cocaine-evoked modifications and drug-driven aversive behaviors. Altogether, our results suggest that long-lasting adaptations in LHb shape negative symptoms after drug taking.
摘要
成瘾性物质介导促进持续药物使用的正负状态。然而，药物厌恶效应的底物仍然难以捉摸。我们发现，在靶向嘴内侧被盖核的小鼠外侧缰核（LHb）神经元中，可卡因增强了谷氨酸能传递，减少了钾离子电流并增加了兴奋性。LHb中的GluA1转运对这些可卡因诱发的改变和药物驱动的厌恶行为起作用。总之，我们的结果表明，LHb中的长期适应性变化塑造了药物摄入后的负面症状。
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