通过腹腔注射胎儿肝细胞诱导山羊胎儿造血嵌合体。
Induction of hemopoietic chimerism in the caprine fetus by intraperitoneal injection of fetal liver cells.
作者信息
Pearce R D, Kiehm D, Armstrong D T, Little P B, Callahan J W, Klunder L R, Clarke J T
机构信息
Department of Pediatrics, University of Toronto, Ontario, Canada.
出版信息
Experientia. 1989 Mar 15;45(3):307-8. doi: 10.1007/BF01951819.
Intraperitoneal injection of allogeneic liver cells from 43-day-old male fetuses into normal 60-day female goat fetuses resulted in persistent hemopoietic chimerism in surviving recipients without clinical evidence of graft-versus-host disease. Transplantation of normal fetal liver cells into preimmunocompetent goat fetuses affected with beta-D-mannosidosis may provide an alternative strategy for evaluating hemopoietic stem cell transplantation in the treatment of human lysosomal storage diseases.
将43日龄雄性胎儿的同种异体肝细胞腹腔注射到正常的60日龄雌性山羊胎儿体内，在存活的受体中产生了持续的造血嵌合体，且没有移植物抗宿主病的临床证据。将正常胎儿肝细胞移植到患有β-D-甘露糖苷贮积症的免疫未成熟山羊胎儿体内，可能为评估造血干细胞移植治疗人类溶酶体贮积病提供一种替代策略。
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