Wagner Anika E, Piegholdt Stefanie, Ferraro Martin, Pallauf Kathrin, Rimbach Gerald
Institute of Human Nutrition and Food Science, Christian-Albrechts-University, Hermann-Rodewald-Str. 6, 24118 Kiel, Germany.
Food Funct. 2015 Mar;6(3):714-8. doi: 10.1039/c4fo01119h.
Foods provide fats, carbohydrates, and proteins as well as vitamins, minerals and trace elements. These dietary factors may influence cellular processes by regulating endogenous microRNA expression. MicroRNAs are non-coding regulatory molecules which affect gene expression at the post transcriptional level. It has been shown that plant and animal derived foods also contain microRNA. Yet, it is unclear if and to what extent plant and animal food derived microRNAs are absorbed by mammals. Thus, future studies need to better address absorption, tissue distribution and function of dietary plant and animal derived microRNAs in the context of human health and disease.
食物提供脂肪、碳水化合物、蛋白质以及维生素、矿物质和微量元素。这些饮食因素可能通过调节内源性微小RNA的表达来影响细胞过程。微小RNA是非编码调节分子,在转录后水平影响基因表达。研究表明,植物和动物源性食物中也含有微小RNA。然而,目前尚不清楚植物和动物源性食物中的微小RNA是否以及在多大程度上被哺乳动物吸收。因此,未来的研究需要在人类健康和疾病的背景下,更好地探讨饮食中植物和动物源性微小RNA的吸收、组织分布和功能。