La Rosa Giusy Rita Maria, Gattuso Giuseppe, Pedullà Eugenio, Rapisarda Ernesto, Nicolosi Daria, Salmeri Mario
Department of General Surgery and Surgical-Medical Specialties, University of Catania, I-95125 Catania, Italy.
Department of Biomedical and Biotechnological Sciences, International PhD Program in Basic and Applied Biomedical Sciences, University of Catania, I-95123 Catania, Italy.
Oncol Lett. 2020 Apr;19(4):3045-3058. doi: 10.3892/ol.2020.11441. Epub 2020 Mar 3.
Oral squamous cell carcinoma (OSCC) is the leading cause of mortality for oral cancer. Numerous risk factors mainly related to unhealthy habits and responsible for chronic inflammation and infections have been recognized as predisposing factors for oral carcinogenesis. Recently, even microbiota alterations have been associated with the development of human cancers. In particular, some specific bacterial strains have been recognized and strongly associated with oral cancer development ( and .). Several hypotheses have been proposed to explain how the oral microbiota could be involved in cancer pathogenesis by mainly paying attention to chronic inflammation, microbial synthesis of cancerogenic substances, and alteration of epithelial barrier integrity. Based on knowledge of the carcinogenic effects of dysbiosis, it was recently suggested that probiotics may have anti-tumoral activity. Nevertheless, few data exist with regard to probiotic effects on oral cancer. On this basis, the association between the development of oral cancer and oral dysbiosis is discussed focusing attention on the potential benefits of probiotics administration in cancer prevention.
口腔鳞状细胞癌（OSCC）是口腔癌致死的主要原因。许多主要与不健康习惯相关且导致慢性炎症和感染的风险因素已被确认为口腔癌发生的诱发因素。最近，微生物群的改变也与人类癌症的发展有关。特别是，一些特定的细菌菌株已被识别并与口腔癌的发展密切相关（以及……）。人们提出了几种假说，主要通过关注慢性炎症、致癌物质的微生物合成以及上皮屏障完整性的改变，来解释口腔微生物群如何参与癌症发病机制。基于对生态失调致癌作用的认识，最近有人提出益生菌可能具有抗肿瘤活性。然而，关于益生菌对口腔癌影响的数据很少。在此基础上，本文讨论了口腔癌发展与口腔生态失调之间的关联，重点关注益生菌给药在癌症预防中的潜在益处。
