通过Pgp-1表达鉴定的记忆性CD4 +辅助性T淋巴细胞亚群。
A subset of memory CD4+ helper T lymphocytes identified by expression of Pgp-1.
作者信息
Butterfield K, Fathman C G, Budd R C
机构信息
Department of Medicine, Stanford University School of Medicine, California 94305.
出版信息
J Exp Med. 1989 Apr 1;169(4):1461-6. doi: 10.1084/jem.169.4.1461.
Abstract
The Pgp-1 glycoprotein (Ly-24 antigen) is acquired by mature murine T lymphocytes at the time of primary antigen stimulation Pgp-1 was previously shown to be a useful cell surface marker for distinguishing antigen-specific memory CD8+ T lymphocytes after immunization. Here we demonstrate that this observation extends to CD4+ T lymphocytes. Antigen-specific CD4+ T cells in mice immunized with sperm whale myoglobin or keyhole limpet hemocyanin were contained nearly exclusively in the minor Pgp-1+ subset.
摘要
Pgp-1糖蛋白（Ly-24抗原）在初次抗原刺激时由成熟的鼠T淋巴细胞获得。Pgp-1先前已被证明是一种有用的细胞表面标志物，用于区分免疫后抗原特异性记忆CD8+T淋巴细胞。在此我们证明这一观察结果也适用于CD4+T淋巴细胞。用抹香鲸肌红蛋白或钥孔戚血蓝蛋白免疫的小鼠中的抗原特异性CD4+T细胞几乎完全包含在较小的Pgp-1+亚群中。
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