Beijing National Laboratory of Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Chem Soc Rev. 2015 Apr 7;44(7):1740-8. doi: 10.1039/c4cs00507d. Epub 2015 Feb 3.
Transamination of α-keto acids with transaminases and pyridoxamine phosphate is an important process to form optically active α-amino acids in biological systems. Various biomimetic transamination systems have been developed for carbonyl compounds including α-keto acid derivatives, fluoroalkyl ketones, and unactivated ketones with chiral vitamin B6 analogues, artificial transaminase mimics, chiral nitrogen sources, and chiral catalysts. This review provides a brief summary of this area.
用转氨酶和磷酸吡哆醛对α-酮酸进行转氨基作用是生物体系中形成光学活性α-氨基酸的重要过程。已经开发了各种仿生转氨基体系来对羰基化合物包括α-酮酸衍生物、氟烷基酮和未活化的酮进行反应，使用的手性维生素 B6 类似物、人工转氨酶模拟物、手性氮源和手性催化剂。本文对该领域进行了简要总结。
