通过不对称仿生转氨作用实现光学活性β-支链α-氨基酸酯的有机催化合成。
Organocatalytic synthesis of optically active β-branched α-amino esters via asymmetric biomimetic transamination.
作者信息
Su Cunxiang, Xie Ying, Pan Hongjie, Liu Mao, Tian Hua, Shi Yian
机构信息
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 10090, China.
出版信息
Org Biomol Chem. 2014 Aug 21;12(31):5856-60. doi: 10.1039/c4ob00684d.
PMID:24969075
Abstract
This paper describes an efficient asymmetric biomimetic transamination of α-keto esters with a quinine-derived chiral base as the catalyst, giving a variety of β-branched α-amino esters in 50-96% yield and 87-95% ee.
摘要
本文描述了一种高效的不对称仿生转氨反应，该反应以奎宁衍生的手性碱为催化剂，将α-酮酯进行转化，以50 - 96%的产率和87 - 95%的对映体过量（ee）得到多种β-支链α-氨基酯。
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