Ortiz Arisa E, Anderson R Rox, Avram Mathew M
Dermatology Cosmetic and Laser Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, 02114; Wellman Center for Photomedicine, Boston, Massachusetts, 02114; UC San Diego, San Diego, California, 92122.
Lasers Surg Med. 2015 Feb;47(2):106-10. doi: 10.1002/lsm.22310. Epub 2015 Feb 2.
Standard surgical and destructive treatments for basal cell carcinoma (BCC) can result in significant morbidity and scarring, stimulating the investigation of alternative non-surgical options. The objective of this study was to determine the safety, clinical, and histological efficacy of pulsed, high-fluence 1064 nm Nd:YAG laser therapy for the treatment of BCC on the trunk and extremities.
STUDY DESIGN/MATERIALS AND METHODS: This was a prospective, non-randomized, open-label clinical trial. Ten subjects with a biopsy-proven BCC less than 1.5 cm in diameter on the trunk or extremities received one treatment with a 10 milliseconds pulsed 1064 nm Nd:YAG laser. Standard excision was performed 1 month after laser treatment to confirm histologic clearance.
The laser treatment was quick and well tolerated. There was complete histologic clearance after one treatment in 92% of the BCC tumors, overall. At higher fluences, there was 100% histologic clearance after one treatment. No significant adverse events were seen, including scarring.
The 1064 nm long-pulsed Nd:YAG laser may offer a safe alternative for treating BCC off the face. A larger study is highly warranted to confirm these preliminary results. Lasers Surg. Med. 47:106-110, 2015. © 2015 Wiley Periodicals, Inc.
基底细胞癌（BCC）的标准手术及破坏性治疗可导致显著的发病率和瘢痕形成，这促使人们对替代性非手术方案进行研究。本研究的目的是确定脉冲、高能量密度1064nm Nd:YAG激光疗法治疗躯干和四肢BCC的安全性、临床及组织学疗效。
研究设计/材料与方法：这是一项前瞻性、非随机、开放标签的临床试验。10例经活检证实直径小于1.5cm的躯干或四肢BCC患者接受了一次10毫秒脉冲1064nm Nd:YAG激光治疗。激光治疗1个月后进行标准切除以确认组织学清除情况。
激光治疗快速且耐受性良好。总体而言，92%的BCC肿瘤经一次治疗后实现了完全组织学清除。在更高能量密度下，一次治疗后组织学清除率达100%。未观察到显著不良事件，包括瘢痕形成。
1064nm长脉冲Nd:YAG激光可能为面部以外部位的BCC治疗提供一种安全的替代方法。非常有必要开展更大规模的研究以证实这些初步结果。《激光外科与医学》47:106 - 110, 2015。© 2015威利期刊公司。
