Soleymani Teo, Abrouk Michael, Kelly Kristen M
*Department of Dermatology, Stanford University School of Medicine, Palo Alto, California; †Department of Dermatology, University of California, Irvine, Irvine, California.
Dermatol Surg. 2017 May;43(5):615-624. doi: 10.1097/DSS.0000000000001048.
Skin cancer remains the most prevalent type of cancer in the United States, and its burden on the health care system remains substantial. Standard treatments such as cryosurgery, electrodessication and curettage, topical and photodynamic therapies, and surgical excision including Mohs micrographic surgery are not without inherent morbidity, including risk of bleeding, infection, and scar.
Lasers may be an alternative for treatment of nonmelanoma skin cancer, and this paper reviews this therapeutic option.
A comprehensive search in the Cochrane Library, MEDLINE, and PUBMED databases was performed to identify relevant literature investigating the role of laser therapy in the treatment of nonmelanoma skin cancer.
New literature regarding laser treatment of nonmelanoma skin cancer is emerging, demonstrating promising clinical outcomes. The greatest efficacy has been seen with vascular-selective and ablative lasers in the treatment of basal cell carcinomas. Some success has been reported for laser treatment of squamous cell carcinoma, but data are less convincing. In summary, laser therapy offers an alternative treatment option for nonmelanoma skin cancer; however, its clinical efficacy is variable and, at this time, remains less than currently accepted standards of care.
Further studies are needed to optimize parameters, determine maximum efficacy, and provide long-term follow-up.
皮肤癌仍是美国最常见的癌症类型，其对医疗保健系统造成的负担依然巨大。诸如冷冻手术、电干燥刮除术、局部和光动力疗法以及包括莫氏显微外科手术在内的手术切除等标准治疗并非没有内在的发病率，包括出血、感染和瘢痕形成风险。
激光可能是治疗非黑色素瘤皮肤癌的一种替代方法，本文对这一治疗选择进行综述。
在考克兰图书馆、MEDLINE和PUBMED数据库中进行全面检索，以识别研究激光疗法在治疗非黑色素瘤皮肤癌中作用的相关文献。
关于激光治疗非黑色素瘤皮肤癌的新文献不断涌现，显示出有前景的临床结果。血管选择性激光和剥脱性激光在治疗基底细胞癌方面疗效最佳。激光治疗鳞状细胞癌也有一些成功报道，但数据说服力较弱。总之，激光疗法为非黑色素瘤皮肤癌提供了一种替代治疗选择；然而，其临床疗效参差不齐，目前仍低于当前公认的护理标准。
需要进一步研究以优化参数、确定最大疗效并提供长期随访。
