头颈部默克尔细胞癌：放疗带来良好预后。
Merkel cell carcinoma of the head and neck: Favorable outcomes with radiotherapy.
作者信息
Bishop Andrew J, Garden Adam S, Gunn G Brandon, Rosenthal David I, Beadle Beth M, Fuller Clifton D, Levy Lawrence B, Gillenwater Ann M, Kies Merrill S, Esmaeli Bita, Frank Steven J, Phan Jack, Morrison William H
机构信息
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
出版信息
Head Neck. 2016 Apr;38 Suppl 1:E452-8. doi: 10.1002/hed.24017. Epub 2015 Jul 14.
BACKGROUND
The purpose of this study was to report the outcomes of patients with Merkel cell carcinoma (MCC) of the head and neck using a radiation-based treatment approach.
METHODS
We reviewed records of 106 consecutive patients with MCC of the head and neck treated with radiation therapy (RT) at our institution between 1988 and 2011. The Kaplan-Meier method was used to estimate outcomes and hazard ratios (HRs) were calculated.
RESULTS
The 5-year actuarial local and regional control rates were 96% and 96%, respectively. There were no regional recurrences in 22 patients treated with RT to gross nodal disease without neck dissection. The 5-year cause-specific survival rate was 76%. Lymphadenopathy at presentation impacted distant metastatic-free survival outcomes (p < .001). Treatment was well tolerated with only 5 patients having grade ≥3 toxicities.
CONCLUSION
For MCC of the head and neck, a management strategy that includes RT offers excellent locoregional control. Gross nodal disease can be successfully treated with RT. © 2015 Wiley Periodicals, Inc. Head Neck 38: E452-E458, 2016.
背景
本研究旨在报告采用基于放疗的治疗方法对头颈部默克尔细胞癌（MCC）患者的治疗结果。
方法
我们回顾了1988年至2011年间在我们机构接受放射治疗（RT）的106例连续性头颈部MCC患者的记录。采用Kaplan-Meier方法评估结果并计算风险比（HRs）。
结果
5年精算局部和区域控制率分别为96%和96%。22例接受单纯放疗而非颈部清扫术治疗的有明显淋巴结疾病患者未出现区域复发。5年病因特异性生存率为76%。就诊时存在淋巴结病影响无远处转移生存结果（p < 0.001）。治疗耐受性良好，仅有5例患者出现≥3级毒性反应。
结论
对于头颈部MCC，包括放疗的治疗策略可提供出色的局部区域控制。明显的淋巴结疾病可通过放疗成功治疗。© 2015威利期刊公司。《头颈》38: E452-E458, 2016。
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