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胰岛素样生长因子结合蛋白-2和-5：正常及肿瘤性乳腺生理学的重要调节因子。

IGFBP-2 and -5: important regulators of normal and neoplastic mammary gland physiology.

作者信息

Beattie James, Hawsawi Yousef, Alkharobi Hanaa, El-Gendy Reem

机构信息

Department of Oral Biology, School of Dentistry, St James University Hospital, Level 7, Wellcome Trust Brenner Building, Leeds, LS9 7TF, UK,

出版信息

J Cell Commun Signal. 2015 Jun;9(2):151-8. doi: 10.1007/s12079-015-0260-3. Epub 2015 Feb 3.

DOI:10.1007/s12079-015-0260-3
PMID:25645979
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4458252/
Abstract

The insulin-like growth factor (IGF) axis plays an important role in mammary gland physiology. In addition, dysregulation of this molecular axis may have a causal role in the aetiology and development of breast cancer (BC). This report discusses the IGF axis in normal and neoplastic mammary gland with special reference to IGF binding proteins (IGFBPs) -2 and -5. We describe how these high affinity binders of IGF-1 and IGF-2 may regulate local actions of growth factors in an autocrine and/or paracrine manner and how they also have IGF-independent effects in mammary gland. We discuss clinical studies which investigate both the prognostic value of IGFBP-2 and -5 expression in BC and possible involvement of these genes in the development of resistance to adjuvant endocrine therapies.

摘要

胰岛素样生长因子（IGF）轴在乳腺生理中起着重要作用。此外，该分子轴的失调可能在乳腺癌（BC）的病因学和发展中起因果作用。本报告讨论了正常和肿瘤性乳腺中的IGF轴，特别提及了IGF结合蛋白（IGFBPs）-2和-5。我们描述了这些IGF-1和IGF-2的高亲和力结合剂如何以自分泌和/或旁分泌方式调节生长因子的局部作用，以及它们如何在乳腺中也具有不依赖IGF的作用。我们讨论了临床研究，这些研究调查了IGFBP-2和-5在BC中的表达的预后价值以及这些基因在辅助内分泌治疗耐药性发展中的可能参与情况。

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本文引用的文献

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Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.位于2q35位点的乳腺癌风险是通过胰岛素样生长因子结合蛋白5（IGFBP5）调控介导的证据。
Nat Commun. 2014 Sep 23;4:4999. doi: 10.1038/ncomms5999.
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Differential subcellular and extracellular localisations of proteins required for insulin-like growth factor- and extracellular matrix-induced signalling events in breast cancer progression.胰岛素样生长因子和细胞外基质诱导的信号事件所需蛋白质在乳腺癌进展中的亚细胞和细胞外差异定位。
BMC Cancer. 2014 Aug 29;14:627. doi: 10.1186/1471-2407-14-627.
3
Exogenous administration of protease-resistant, non-matrix-binding IGFBP-2 inhibits tumour growth in a murine model of breast cancer.外源性给予蛋白酶抗性、非基质结合 IGFBP-2 可抑制乳腺癌小鼠模型中的肿瘤生长。
Br J Cancer. 2014 Jun 10;110(12):2855-64. doi: 10.1038/bjc.2014.232. Epub 2014 May 22.
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Effects of physiological levels of the green tea extract epigallocatechin-3-gallate on breast cancer cells.表没食子儿茶素没食子酸酯对乳腺癌细胞的影响。
Front Endocrinol (Lausanne). 2014 May 7;5:61. doi: 10.3389/fendo.2014.00061. eCollection 2014.
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Loss of PTEN expression is associated with IGFBP2 expression, younger age, and late stage in triple-negative breast cancer.PTEN表达缺失与三阴性乳腺癌中的IGFBP2表达、较年轻年龄及晚期相关。
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