胰岛素样生长因子结合蛋白-2和-5：正常及肿瘤性乳腺生理学的重要调节因子。
IGFBP-2 and -5: important regulators of normal and neoplastic mammary gland physiology.
作者信息
Beattie James, Hawsawi Yousef, Alkharobi Hanaa, El-Gendy Reem
机构信息
Department of Oral Biology, School of Dentistry, St James University Hospital, Level 7, Wellcome Trust Brenner Building, Leeds, LS9 7TF, UK,
出版信息
J Cell Commun Signal. 2015 Jun;9(2):151-8. doi: 10.1007/s12079-015-0260-3. Epub 2015 Feb 3.
Abstract
The insulin-like growth factor (IGF) axis plays an important role in mammary gland physiology. In addition, dysregulation of this molecular axis may have a causal role in the aetiology and development of breast cancer (BC). This report discusses the IGF axis in normal and neoplastic mammary gland with special reference to IGF binding proteins (IGFBPs) -2 and -5. We describe how these high affinity binders of IGF-1 and IGF-2 may regulate local actions of growth factors in an autocrine and/or paracrine manner and how they also have IGF-independent effects in mammary gland. We discuss clinical studies which investigate both the prognostic value of IGFBP-2 and -5 expression in BC and possible involvement of these genes in the development of resistance to adjuvant endocrine therapies.
摘要
胰岛素样生长因子（IGF）轴在乳腺生理中起着重要作用。此外，该分子轴的失调可能在乳腺癌（BC）的病因学和发展中起因果作用。本报告讨论了正常和肿瘤性乳腺中的IGF轴，特别提及了IGF结合蛋白（IGFBPs）-2和-5。我们描述了这些IGF-1和IGF-2的高亲和力结合剂如何以自分泌和/或旁分泌方式调节生长因子的局部作用，以及它们如何在乳腺中也具有不依赖IGF的作用。我们讨论了临床研究，这些研究调查了IGFBP-2和-5在BC中的表达的预后价值以及这些基因在辅助内分泌治疗耐药性发展中的可能参与情况。
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