Young VyVy N, Gartner-Schmidt Jackie, Rosen Clark A
Department of Otolaryngology, University of Pittsburgh Voice Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.
Laryngoscope. 2015 Apr;125(4):934-40. doi: 10.1002/lary.25043. Epub 2015 Feb 3.
OBJECTIVES/HYPOTHESIS: To compare voice outcomes after vocal fold augmentation using a trial (temporary) vocal fold injection (VFI) versus long-term augmentation in patients diagnosed with vocal fold atrophy.
Retrospective, single-blinded study.
Nineteen patients diagnosed with vocal fold atrophy underwent trial VFI and subsequent long-term augmentation. Voice Handicap Index-10, acoustic, and aerodynamic measures were analyzed following trial and long-term augmentation procedures.
Forty-two percent (8/19) of patients had a good response to trial VFI (P < .0001); 58% (11/19) had a poor response to trial VFI (P = .95). Of the patients with good response to trial VFI, 75% (6/8) also had good response to long-term augmentation (P = .006), but 25% (2/8) reported a poor response to long-term treatment. Of the patients who had a poor response to trial VFI, 55% (6/11) also had a poor response to long-term treatment, but 45% (5/11) of patients reported good response after long-term augmentation.
This is the first study to provide comparative voice outcomes using both trial VFI and long-term augmentation for vocal fold atrophy. Additional critical evaluation of the value of trial VFI for vocal fold atrophy patients is suggested.
目的/假设：比较诊断为声带萎缩的患者采用试验性（临时性）声带注射（VFI）与长期强化治疗后的嗓音结果。
回顾性单盲研究。
19例诊断为声带萎缩的患者接受了试验性VFI及随后的长期强化治疗。在试验性和长期强化治疗后，对嗓音障碍指数-10、声学和空气动力学指标进行分析。
42%（8/19）的患者对试验性VFI反应良好（P < 0.0001）；58%（11/19）的患者对试验性VFI反应不佳（P = 0.95）。对试验性VFI反应良好的患者中，75%（6/8）对长期强化治疗也反应良好（P = 0.006），但25%（2/8）的患者报告对长期治疗反应不佳。对试验性VFI反应不佳的患者中，55%（6/11）对长期治疗也反应不佳，但45%（5/11）的患者报告长期强化治疗后反应良好。
这是第一项同时使用试验性VFI和长期强化治疗来比较声带萎缩患者嗓音结果的研究。建议对试验性VFI在声带萎缩患者中的价值进行更多关键评估。
