Sotiri Irini, Overton Jonathan C, Waterhouse Anna, Howell Caitlin
Wyss Institute for Biologically Inspired Engineering, Boston, MA 02115 USA John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
Department of Chemical and Biological Engineering, University of Maine, Orono, ME 04469, USA.
Exp Biol Med (Maywood). 2016 May;241(9):909-18. doi: 10.1177/1535370216640942. Epub 2016 Mar 27.
Surface fouling and undesired adhesion are nearly ubiquitous problems in the medical field, complicating everything from surgeries to routine daily care of patients. Recently, the concept of immobilized liquid (IL) interfaces has been gaining attention as a highly versatile new approach to antifouling, with a wide variety of promising applications in medicine. Here, we review the general concepts behind IL layers and discuss the fabrication strategies on medically relevant materials developed so far. We also summarize the most important findings to date on applications of potential interest to the medical community, including the use of these surfaces as anti-thrombogenic and anti-bacterial materials, anti-adhesive textiles, high-performance coatings for optics, and as unique platforms for diagnostics. Although the full potential and pitfalls of IL layers in medicine are just beginning to be explored, we believe that this approach to anti-adhesive surfaces will prove broadly useful for medical applications in the future.
表面污垢和不必要的粘附是医学领域几乎普遍存在的问题，使从手术到患者日常护理的一切都变得复杂。最近，固定化液体（IL）界面的概念作为一种高度通用的新型防污方法受到关注，在医学领域有各种各样有前景的应用。在这里，我们回顾了IL层背后的一般概念，并讨论了迄今为止在医学相关材料上的制备策略。我们还总结了迄今为止医学领域潜在感兴趣的应用的最重要发现，包括将这些表面用作抗血栓形成和抗菌材料、抗粘附纺织品、光学高性能涂层以及独特的诊断平台。尽管IL层在医学中的全部潜力和缺陷才刚刚开始被探索，但我们相信这种抗粘附表面的方法在未来的医学应用中将被证明具有广泛的用途。
