Department of Stomatology, Second Hospital, Jilin University, 130041, Changchun, China.
College of Chemistry, Jilin University, Qianjin Street, 130012, Changchun, China.
J Mater Sci Mater Med. 2018 Apr 23;29(5):50. doi: 10.1007/s10856-018-6042-8.
Postoperative infection associated with medical implants is a devastating complication of orthopedic surgery. Considering the difficulties for the diagnosis and treatment of infection, coating the implant material with antibacterial substances is a promising protocol by which to avoid such an adverse reaction. Nanoparticles (NPs) constructed of anatase microspheres, one form of titanium dioxide (TiO), with a high specific surface area are fabricated in this study in a facile one-step process using homogeneous precipitation at 90 °C under atmospheric pressure using titanium sulfate (Ti[SO]) and urea as the titanium source and precipitant, respectively. The molar ratio of silver (Ag) to TiO can be changed by varying the amount of silver nitrate (AgNO). The high specific surface area of the TiO microspheres combined with Ag particles (Ag/TiO) exhibit excellent antibacterial properties against both Staphylococcus aureus and Escherichia coli. In addition, the Ag/TiO material in this work possesses satisfactory biological performance on MC3T3-E1 cells. The high specific surface area of Ag/TiO together with good antibacterial properties and cytocompatibility provide promising applications in dentistry, orthopedics, and other fields of medicine that use biomedical devices.
术后感染与医用植入物相关，是骨科手术的一种毁灭性并发症。鉴于感染的诊断和治疗困难，用抗菌物质涂覆植入材料是一种很有前途的方案，可以避免这种不良反应。本研究采用均相沉淀法，在 90°C 常压下，以硫酸钛（Ti[SO]）和尿素分别作为钛源和沉淀剂，一步制备出具有高比表面积的锐钛矿型二氧化钛（TiO）纳米粒子（NPs）微球。通过改变硝酸银（AgNO）的用量，可以改变银（Ag）与 TiO 的摩尔比。TiO 微球的高比表面积与 Ag 颗粒（Ag/TiO）结合，对金黄色葡萄球菌和大肠杆菌均具有优异的抗菌性能。此外，本工作中的 Ag/TiO 材料对 MC3T3-E1 细胞具有良好的生物学性能。Ag/TiO 具有高比表面积、良好的抗菌性能和细胞相容性，为牙科、骨科和其他使用生物医学器械的医学领域提供了有前途的应用。
