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拟南芥HFR1是一种受丁香假单胞菌III型效应蛋白XopD（Xcc8004）调控的潜在核底物。

Arabidopsis HFR1 is a potential nuclear substrate regulated by the Xanthomonas type III effector XopD(Xcc8004).

作者信息

Tan Choon Meng, Li Meng-Ying, Yang Pei-Yun, Chang Shu Heng, Ho Yi-Ping, Lin Hong, Deng Wen-Ling, Yang Jun-Yi

机构信息

Institute of Biochemistry, National ChungHsing University, Taichung, Taiwan; Ph.D. Program in Microbial Genomics, National ChungHsing University and Academia Sinica, Taipei, Taiwan.

Institute of Biochemistry, National ChungHsing University, Taichung, Taiwan.

出版信息

PLoS One. 2015 Feb 3;10(2):e0117067. doi: 10.1371/journal.pone.0117067. eCollection 2015.

DOI:10.1371/journal.pone.0117067
PMID:25647296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4315394/
Abstract

XopDXcc8004, a type III effector of Xanthomonas campestris pv. campestris (Xcc) 8004, is considered a shorter version of the XopD, which lacks the N-terminal domain. To understand the functions of XopDXcc8004, in planta, a transgenic approach combined with inducible promoter to analyze the effects of XopDXcc8004 in Arabidopsis was done. Here, the expression of XopDXcc8004, in Arabidopsis elicited the accumulation of host defense-response genes. These molecular changes were dependent on salicylic acid and correlated with lesion-mimic phenotypes observed in XVE::XopDXcc8004 transgenic plants. Moreover, XopDXcc8004 was able to desumoylate HFR1, a basic helix-loop-helix transcription factor involved in photomorphogenesis, through SUMO protease activity. Interestingly, the hfr1-201 mutant increased the expression of host defense-response genes and displayed a resistance phenotype to Xcc8004. These data suggest that HFR1 is involved in plant innate immunity and is potentially regulated by XopDXcc8004.

摘要

XopDXcc8004是野油菜黄单胞菌野油菜致病变种（Xcc）8004的III型效应蛋白，被认为是XopD的较短版本，缺少N端结构域。为了解XopDXcc8004在植物体内的功能，采用转基因方法结合诱导型启动子来分析XopDXcc8004在拟南芥中的作用。在此，XopDXcc8004在拟南芥中的表达引发了宿主防御反应基因的积累。这些分子变化依赖于水杨酸，并与在XVE::XopDXcc8004转基因植物中观察到的类病斑表型相关。此外，XopDXcc8004能够通过SUMO蛋白酶活性使HFR1去SUMO化，HFR1是一种参与光形态建成的碱性螺旋-环-螺旋转录因子。有趣的是，hfr1-201突变体增加了宿主防御反应基因的表达，并对Xcc8004表现出抗性表型。这些数据表明，HFR1参与植物先天免疫，并可能受XopDXcc8004调控。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/4315394/4da0f9a7b849/pone.0117067.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/4315394/fcdb6e129582/pone.0117067.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/4315394/c0a68a50dca6/pone.0117067.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/4315394/addba8f5995b/pone.0117067.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/4315394/1f34dfdc5f68/pone.0117067.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/4315394/516174c56d8d/pone.0117067.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/4315394/f6ff416596fd/pone.0117067.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/4315394/4da0f9a7b849/pone.0117067.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/4315394/fcdb6e129582/pone.0117067.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/4315394/c0a68a50dca6/pone.0117067.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/4315394/addba8f5995b/pone.0117067.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/4315394/1f34dfdc5f68/pone.0117067.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/4315394/516174c56d8d/pone.0117067.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/4315394/f6ff416596fd/pone.0117067.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1e9/4315394/4da0f9a7b849/pone.0117067.g007.jpg

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