Xiang Hui, Stojilkovic Boris, Gheysen Godelieve
Faculty of Bioscience Engineering, Ghent University, Gent, Belgium.
John Innes Centre, Norwich, UK.
Mol Plant Pathol. 2025 Jan;26(1):e70057. doi: 10.1111/mpp.70057.
In the coevolutionary process between plant pathogens and hosts, pathogen effectors, primarily proteinaceous, engage in interactions with host proteins, such as plant transcription factors (TFs), during the infection process. This review delves into the intricate interplay between TFs and effectors, a key aspect in the prolonged and complex battle between plants and pathogens. Effectors strategically manipulate TFs using diverse tactics. These include modulating activity of TFs, influencing their incorporation into multimeric complexes, directly changing TF expression levels, promoting their degradation via the ubiquitin-proteasome system, and inducing their subcellular relocalization. The review systematically presents documented interactions, elucidating key mechanisms and their profound impact on host-pathogen dynamics. It emphasises the central role of TFs in plant defence and investigates the convergent evolution of effectors targeting TFs. By providing this overview, we offer valuable insights into this dynamic interaction landscape and suggest potential directions for future research.
在植物病原体与宿主的共同进化过程中，病原体效应子（主要为蛋白质）在感染过程中与宿主蛋白（如植物转录因子）发生相互作用。本综述深入探讨了转录因子与效应子之间的复杂相互作用，这是植物与病原体长期复杂斗争中的一个关键方面。效应子通过多种策略巧妙地操纵转录因子。这些策略包括调节转录因子的活性、影响它们掺入多聚体复合物、直接改变转录因子的表达水平、通过泛素 - 蛋白酶体系统促进其降解以及诱导其亚细胞重新定位。该综述系统地展示了已记录的相互作用，阐明了关键机制及其对宿主 - 病原体动态的深远影响。它强调了转录因子在植物防御中的核心作用，并研究了靶向转录因子的效应子的趋同进化。通过提供这一概述，我们对这一动态相互作用格局提供了有价值的见解，并为未来研究提出了潜在方向。
