Yamamoto Tetsushi, Uemura Kentaro, Moriyama Kaho, Mitamura Kuniko, Taga Atsushi
Pathological and Biomolecule Analyses Laboratory, Faculty of Pharmacy, Kinki University, Higashi-Osaka, Osaka 577-8502, Japan.
Oncol Rep. 2015 Apr;33(4):1579-84. doi: 10.3892/or.2015.3777. Epub 2015 Feb 2.
Maple syrup is a natural sweetener consumed by individuals of all ages throughout the world. Maple syrup contains not only carbohydrates such as sucrose but also various components such as organic acids, amino acids, vitamins and phenolic compounds. Recent studies have shown that these phenolic compounds in maple syrup may possess various activities such as decreasing the blood glucose level and an anticancer effect. In this study, we examined the effect of three types of maple syrup, classified by color, on the cell proliferation, migration and invasion of colorectal cancer (CRC) cells in order to investigate whether the maple syrup is suitable as a phytomedicine for cancer treatment. CRC cells that were administered maple syrup showed significantly lower growth rates than cells that were administered sucrose. In addition, administration of maple syrup to CRC cells caused inhibition of cell invasion, while there was no effect on cell migration. Administration of maple syrup clearly inhibited AKT phosphorylation, while there was no effect on ERK phosphorylation. These data suggest that maple syrup might inhibit cell proliferation and invasion through suppression of AKT activation and be suitable as a phytomedicine for CRC treatment, with fewer adverse effects than traditional chemotherapy.
枫糖浆是一种全世界各年龄段人群都会食用的天然甜味剂。枫糖浆不仅含有碳水化合物，如蔗糖，还含有各种成分，如有机酸、氨基酸、维生素和酚类化合物。最近的研究表明，枫糖浆中的这些酚类化合物可能具有多种活性，如降低血糖水平和抗癌作用。在本研究中，我们研究了按颜色分类的三种枫糖浆对结肠直肠癌（CRC）细胞的增殖、迁移和侵袭的影响，以调查枫糖浆是否适合作为癌症治疗的植物药。给予枫糖浆的CRC细胞的生长速率明显低于给予蔗糖的细胞。此外，给CRC细胞施用枫糖浆会抑制细胞侵袭，但对细胞迁移没有影响。施用枫糖浆明显抑制AKT磷酸化，但对ERK磷酸化没有影响。这些数据表明，枫糖浆可能通过抑制AKT激活来抑制细胞增殖和侵袭，并且适合作为CRC治疗的植物药，其副作用比传统化疗更少。
