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从甲酰胺到核糖核酸，这条路径虽曲折但连贯。

From formamide to RNA, the path is tenuous but continuous.

作者信息

Pino Samanta, Sponer Judit E, Costanzo Giovanna, Saladino Raffaele, Mauro Ernesto Di

机构信息

Fondazione "Istituto Pasteur-Fondazione Cenci-Bolognetti" c/o Dipartimento di Biologia e Biotecnologie "Charles Darwin", "Sapienza" Università di Roma, P.le Aldo Moro, 5, 00185 Rome, Italy.

Institute of Biophysics, Academy of Sciences of the Czech Republic, Královopolská 135, 61265 Brno, Czech Republic.

出版信息

Life (Basel). 2015 Jan 30;5(1):372-84. doi: 10.3390/life5010372.

DOI:10.3390/life5010372
PMID:25647486
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4390857/
Abstract

Reactions of formamide (NH2COH) in the presence of catalysts of both terrestrial and meteoritic origin yield, in plausible and variegated conditions, a large panel of precursors of (pre)genetic and (pre)metabolic interest. Formamide chemistry potentially satisfies all of the steps from the very initial precursors to RNA. Water chemistry enters the scene in RNA non-enzymatic synthesis and recombination.

摘要

在地球和陨石来源的催化剂存在下，甲酰胺（NH2COH）的反应在合理且多样的条件下产生了大量具有（前）遗传和（前）代谢意义的前体物质。甲酰胺化学有可能满足从最初的前体物质到RNA的所有步骤。水化学在RNA的非酶促合成和重组过程中发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a742/4390857/c87f66867d40/life-05-00372-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a742/4390857/9125a50ad2eb/life-05-00372-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a742/4390857/47f21f421daa/life-05-00372-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a742/4390857/299ab8001627/life-05-00372-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a742/4390857/ea45580f0560/life-05-00372-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a742/4390857/fde5af293714/life-05-00372-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a742/4390857/322e368174b4/life-05-00372-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a742/4390857/c87f66867d40/life-05-00372-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a742/4390857/9125a50ad2eb/life-05-00372-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a742/4390857/47f21f421daa/life-05-00372-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a742/4390857/299ab8001627/life-05-00372-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a742/4390857/ea45580f0560/life-05-00372-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a742/4390857/fde5af293714/life-05-00372-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a742/4390857/322e368174b4/life-05-00372-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a742/4390857/c87f66867d40/life-05-00372-g007.jpg

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