Stubbs R S, Stabile B E
Department of Surgery, Clinical School of Medicine, Wellington, New Zealand.
Arch Surg. 1989 Apr;124(4):473-8. doi: 10.1001/archsurg.1989.01410040083020.
To investigate the possible exocrine pancreatic inhibitory actions of amino acids and fat, pancreatic fistula outputs and plasma concentrations of glucagon, somatostatin, and pancreatic polypeptide were measured for response to intravenous (IV) and intraduodenal nutrient administration in six dogs submaximally stimulated with cholecystokinin. Intravenous amino acids caused abrupt and significant 45% to 73% reductions in stimulated pancreatic protein, bicarbonate, and volume outputs. There were no significant associated changes in plasma hormone concentrations and no similar immediate pancreatic inhibition with IV mannitol, thus suggesting a possible direct inhibitory effect of amino acids. Intraduodenal amino acids and IV fat evoked no significant pancreatic output suppression. Intraduodenal fat rapidly caused a significant 40% to 62% reductions in stimulated outputs that were associated with an 81% rise in plasma pancreatic polypeptide concentration, suggesting a gut-mediated inhibition. We conclude that IV amino acids and intraduodenal fat both inhibited stimulated pancreatic secretion but probably by different mechanisms.
为研究氨基酸和脂肪对胰腺外分泌的可能抑制作用，对六只接受胆囊收缩素次最大刺激的犬，测定了胰瘘排出量以及胰高血糖素、生长抑素和胰多肽的血浆浓度，以观察它们对静脉内（IV）和十二指肠内给予营养物质的反应。静脉内给予氨基酸导致刺激后的胰腺蛋白质、碳酸氢盐和液体排出量突然且显著降低45%至73%。血浆激素浓度无显著相关变化，静脉内给予甘露醇也未产生类似的即时胰腺抑制作用，因此提示氨基酸可能具有直接抑制作用。十二指肠内给予氨基酸和静脉内给予脂肪未引起胰腺排出量的显著抑制。十二指肠内给予脂肪迅速导致刺激后的排出量显著降低40%至62%，这与血浆胰多肽浓度升高81%相关，提示存在肠道介导的抑制作用。我们得出结论，静脉内给予氨基酸和十二指肠内给予脂肪均抑制了刺激后的胰腺分泌，但可能通过不同机制。
