Shiratori K, Watanabe S, Takeuchi T
Department of Medicine and Gastroenterology, Tokyo Women's Medical College, Japan.
Pancreas. 1993 Jul;8(4):471-5. doi: 10.1097/00006676-199307000-00011.
The inhibitory effect of the intraduodenal administration of a new somatostatin analogue, SDZ CO 611 (SDZ), on pancreatic secretion was evaluated in the rat. The exocrine pancreas was stimulated by either intravenous infusion of both secretion (0.06 CU/kg/h) and cholecystokinin octapeptide (CCK-8) (0.03 microgram/kg/h) or intraduodenal infusion of oleic acid (0.25 mmol/h) or casein (200 mg/h). Intraduodenal administration of SDZ in three different doses, 0.5, 1.0, and 2.0 mg/kg/h, resulted in dose-related inhibition of pancreatic secretion, including juice volume, bicarbonate, and amylase, stimulated by exogenous secretin and CCK. Intraduodenal oleic acid- and casein-induced increases in pancreatic secretion in terms of juice volume, bicarbonate, and amylase were also significantly suppressed by intraduodenal administration of SDZ in a dose of 2.0 mg/kg/h. Moreover, SDZ (2.0 mg/kg/h) significantly inhibited basal pancreatic secretion. It is concluded that the intraduodenal administration of SDZ inhibits pancreatic secretion stimulated by exogenous secretin and CCK-8 in physiological doses and by intestinal nutrients in the rat.
在大鼠中评估了十二指肠内给予一种新的生长抑素类似物SDZ CO 611（SDZ）对胰腺分泌的抑制作用。通过静脉输注促胰液素（0.06 CU/kg/h）和八肽胆囊收缩素（CCK-8）（0.03微克/千克/小时）或十二指肠内输注油酸（0.25毫摩尔/小时）或酪蛋白（200毫克/小时）来刺激外分泌胰腺。以0.5、1.0和2.0毫克/千克/小时这三种不同剂量十二指肠内给予SDZ，导致胰腺分泌呈剂量相关的抑制，包括由外源性促胰液素和CCK刺激产生的胰液量、碳酸氢盐和淀粉酶。十二指肠内给予2.0毫克/千克/小时剂量的SDZ也显著抑制了十二指肠内油酸和酪蛋白诱导的胰液量、碳酸氢盐和淀粉酶方面的胰腺分泌增加。此外，SDZ（2.0毫克/千克/小时）显著抑制基础胰腺分泌。得出的结论是，十二指肠内给予SDZ可抑制大鼠中由生理剂量的外源性促胰液素和CCK-8以及肠道营养物质刺激产生的胰腺分泌。
