Woody Mary L, Kudinova Anastacia Y, McGeary John E, Knopik Valerie S, Palmer Rohan H C, Gibb Brandon E
a Department of Psychology , Binghamton University (SUNY) , Binghamton , NY , USA.
b Providence Veterans Affairs Medical Center , Providence , RI , USA.
Cogn Emot. 2016;30(2):302-14. doi: 10.1080/02699931.2014.998631. Epub 2015 Feb 3.
There is growing evidence that brooding rumination plays a key role in the intergenerational transmission of major depressive disorder (MDD) and may be an endophenotype for depression risk. However, less is known about the mechanisms underlying this role. Therefore, the goal of the current study was to examine levels of brooding in children of mothers with a history of MDD (n = 129) compared to children of never depressed mothers (n = 126) and to determine whether the variation in a gene known to influence hypothalamic-pituitary-adrenal axis functioning--corticotropin-releasing hormone receptor 1 (CRHR1)--would moderate the link between maternal MDD and children's levels of brooding. We predicted children of mothers with a history of MDD would exhibit higher levels of brooding than children of mothers with no lifetime depression history but that this link would be stronger among children carrying no copies of the protective CRHR1 TAT haplotype. Our results supported these hypotheses and suggest that the development of brooding among children of depressed mothers, particularly children without the protective CRHR1 haplotype, may serve as an important mechanism of risk for the intergenerational transmission of depression.
越来越多的证据表明，沉思性反刍在重度抑郁症（MDD）的代际传递中起关键作用，并且可能是抑郁风险的一种内表型。然而，对于这一作用背后的机制却知之甚少。因此，本研究的目的是比较有MDD病史的母亲的孩子（n = 129）与从未患抑郁症的母亲的孩子（n = 126）的沉思水平，并确定一种已知会影响下丘脑 - 垂体 - 肾上腺轴功能的基因——促肾上腺皮质激素释放激素受体1（CRHR1）——的变异是否会调节母亲患MDD与孩子沉思水平之间的联系。我们预测，有MDD病史的母亲的孩子比没有终生抑郁病史的母亲的孩子表现出更高的沉思水平，但这种联系在没有携带保护性CRHR1 TAT单倍型的孩子中会更强。我们的结果支持了这些假设，并表明抑郁母亲（尤其是没有保护性CRHR1单倍型的孩子）的孩子中沉思的发展可能是抑郁症代际传递风险的一个重要机制。
