Chan Ching Ching Kate, Au Chun T, Lam Hugh S, Lee Dennis L Y, Wing Yun K, Li Albert M
Department of Pediatrics, Otorhinolaryngology - Head and Neck Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Department of Pediatrics, Otorhinolaryngology - Head and Neck Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Sleep Med. 2015 Mar;16(3):358-63. doi: 10.1016/j.sleep.2014.10.015. Epub 2015 Jan 15.
The use of non-surgical treatment for childhood obstructive sleep apnea (OSA) is gaining popularity, especially in children with mild disease.
To test the hypothesis that intranasal corticosteroids reduce disease severity in children with mild OSA.
A randomized, double-blinded, placebo-controlled trial of intranasal mometasone furoate (MF) versus placebo in children aged 6 to 18 years with mild OSA. The primary outcome was the change from baseline obstructive apnea hypopnea index (OAHI), as documented by overnight polysomnography, after four months of treatment.
Sixty-two children were recruited but 12 dropped out. This left 24 and 26 children for final analysis in the MF and placebo group, respectively. The OAHI and oxygen desaturation index (ODI) improved significantly in the MF group only. The OAHI decreased from 2.7 ± 0.2 to 1.7 ± 0.3 in the MF group, but increased from 2.5 ± 0.2 to 2.9 ± 0.6 in the placebo group (p = 0.039). The mean changes in ODI in the MF group and placebo group were -0.6 ± 0.5 and +0.7 ± 0.4, respectively (p = 0.037).
Four months of treatment with intranasal mometasone furoate effectively reduces the severity of mild OSA in children.
非手术治疗儿童阻塞性睡眠呼吸暂停（OSA）的方法越来越受欢迎，尤其是对于轻度疾病的儿童。
检验鼻内皮质类固醇可降低轻度OSA儿童疾病严重程度这一假设。
一项针对6至18岁轻度OSA儿童的糠酸莫米松（MF）鼻内给药与安慰剂对照的随机双盲试验。主要结局是治疗四个月后，通过夜间多导睡眠图记录的阻塞性呼吸暂停低通气指数（OAHI）相对于基线的变化。
招募了62名儿童，但12名退出。这使得MF组和安慰剂组分别有24名和26名儿童进行最终分析。仅MF组的OAHI和氧饱和度下降指数（ODI）有显著改善。MF组的OAHI从2.7±0.2降至1.7±0.3，而安慰剂组从2.5±0.2升至2.9±0.6（p = 0.039）。MF组和安慰剂组ODI的平均变化分别为-0.6±0.5和+0.7±0.4（p = 0.037）。
糠酸莫米松鼻内给药四个月可有效降低儿童轻度OSA的严重程度。
