Leung Theresa Nh, Cheng James Wch, Chan Anthony Kc
Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong SAR, China.
Department of Paediatrics and Adolescent Medicine, United Christian Hospital, Hong Kong SAR, China.
Drugs Context. 2021 Mar 26;10. doi: 10.7573/dic.2020-12-5. eCollection 2021.
Obstructive sleep apnoea syndrome (OSAS) is defined as the intermittent reduction or cessation of airflow due to partial or complete obstruction of the upper airway during sleep. Paediatric OSAS has specific contributing factors, presenting symptoms and management strategies in various age groups. Untreated OSAS can lead to detrimental effects on neurocognitive development and cardiovascular and metabolic functions of a growing child. In the past decade, practice guidelines have been developed to guide the evaluation and management of OSAS. This article provides a narrative review on the current diagnostic and treatment options for paediatric OSAS. Alternative diagnostic tools other than the standard polysomnography are discussed. Adenotonsillectomy is considered the first-line therapy yet it is not suitable for treatment of all OSAS cases. Nocturnal non-invasive positive airway pressure ventilation is effective and could be the priority treatment for patients with complex comorbidities, residual OSAS post-adenotonsillectomy or obesity. However, intolerance and non-adherence are major challenges of positive airway pressure therapy especially in young children. There is increasing evidence for watchful waiting and other gentler alternative treatment options in mild OSAS. The role of anti-inflammatory drugs as the primary or adjunctive treatment is discussed. Other treatment options, including weight reduction, orthodontic procedures and myofunctional therapy, are indicated for selected patients. Nevertheless, the successful management of paediatric OSAS often requires a multidisciplinary team approach.
阻塞性睡眠呼吸暂停综合征(OSAS)的定义为睡眠期间由于上气道部分或完全阻塞导致气流间歇性减少或停止。小儿OSAS有特定的促成因素,在不同年龄组有不同的症状表现和管理策略。未经治疗的OSAS会对成长中儿童的神经认知发育以及心血管和代谢功能产生有害影响。在过去十年中,已制定了实践指南以指导OSAS的评估和管理。本文对小儿OSAS当前的诊断和治疗选择进行叙述性综述。讨论了除标准多导睡眠图之外的其他诊断工具。腺样体扁桃体切除术被视为一线治疗方法,但它并不适用于所有OSAS病例。夜间无创正压通气有效,对于有复杂合并症、腺样体扁桃体切除术后仍有残余OSAS或肥胖的患者可能是优先治疗方法。然而,不耐受和不依从是正压通气治疗的主要挑战,尤其是在幼儿中。越来越多的证据支持对轻度OSAS进行观察等待和其他更温和的替代治疗选择。讨论了抗炎药物作为主要或辅助治疗的作用。其他治疗选择,包括减重、正畸程序和肌功能治疗,适用于特定患者。尽管如此,小儿OSAS的成功管理通常需要多学科团队方法。