Gando S, Kamiya K, Makise H, Tedo I, Nakanishi Y
Department of Emergency and Critical Care Medicine, Sapporo City General Hospital, Japan.
Nihon Geka Gakkai Zasshi. 1989 Jan;90(1):59-63.
Serial changes of FPA, FPB beta 15-42, FN, XIIIa, and alpha 2PI were investigated for the study on wound healing, blood coagulation, and fibrinolysis during gastric cancer surgery. For a control, we compared the preoperative values with the postoperative ones. These results also were compared with the values in healthy volunteers and in patients with cholelithiasis or myoma uteri. Our findings were as follows; 1) Compared with the control values, a statistically significant elevation of FPA, FPB beta 15-42 and FPA/FPB beta 15-42 ratios in patients with gastric cancer was noticed after operation. 2) Compared with the control values, a statistically marked decrease of FN, XIIIa and alpha 2PI in patients with gastric cancer was observed after operation. 3) The preoperative FPA and FPB beta 15-42 levels of gastric cancer patients were appreciably greater than those of normal healthy volunteers. Compared with patients with cholelithiasis or myoma uteri, however, the only preoperative FPA of gastric cancer patients showed significantly high levels. 4) FN and alpha 2PI revealed a notable positive correlation. These results suggest (1) increase of coagulation activity (thrombin formation) in gastric cancer patients; (2) increase of intravascular coagulation and fibrinolytic activity (thrombin and plasmin formation) during gastric cancer surgery; and, (3) depression of FN, XIIIa and alpha 2PI during surgery was due to sequestration at the site of tissue injury.
为研究胃癌手术期间的伤口愈合、血液凝固和纤维蛋白溶解情况，对FPA、FPBβ15 - 42、FN、XIIIa和α2PI的系列变化进行了调查。作为对照，我们将术前值与术后值进行了比较。这些结果还与健康志愿者以及患有胆结石或子宫肌瘤患者的值进行了比较。我们的研究结果如下：1）与对照值相比，胃癌患者术后FPA、FPBβ15 - 42以及FPA/FPBβ15 - 42比值有统计学意义的升高。2）与对照值相比，胃癌患者术后FN、XIIIa和α2PI有统计学意义的显著降低。3）胃癌患者术前的FPA和FPBβ15 - 42水平明显高于正常健康志愿者。然而，与患有胆结石或子宫肌瘤的患者相比，仅胃癌患者术前的FPA显示出显著的高水平。4）FN和α2PI显示出显著的正相关。这些结果表明：（1）胃癌患者凝血活性（凝血酶形成）增加；（2）胃癌手术期间血管内凝血和纤维蛋白溶解活性（凝血酶和纤溶酶形成）增加；以及，（3）手术期间FN、XIIIa和α2PI的降低是由于在组织损伤部位的隔离。
