Yacoub Sophie, Wills Bridget
Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, and specialist registrar in infectious diseases, Imperial College, Department of Medicine, London, UK
Wellcome Trust Major Overseas Programme, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, and professor of tropical medicine, Nuffield Department of Clinical Medicine, Centre for Tropical Medicine, Oxford, UK.
Clin Med (Lond). 2015 Feb;15(1):82-5. doi: 10.7861/clinmedicine.15-1-82.
Dengue is one of the most rapidly emerging viral infections globally, with 2.5 billion people now thought to live in dengue-endemic areas. In addition, reports of travel-related and autochthonous infections are increasing in non-endemic areas. Most patients with dengue experience a self-limiting febrile illness, but a proportion develop potentially life threatening complications around the time of fever clearance, including plasma leakage occasionally leading to shock, bleeding, and organ impairment. As dengue can present with non-specific symptoms of fever, headache and myalgias, the potential for misdiagnosis and inappropriate management by medical staff inexperienced with the disease is a concern. This short review will outline the latest World Health Organisation disease classification, potential complications, clinical assessment and management for clinicians working in non-endemic areas.
登革热是全球最迅速出现的病毒感染之一，目前据信有25亿人生活在登革热流行地区。此外，非流行地区与旅行相关和本地感染的报告也在增加。大多数登革热患者经历自限性发热疾病，但一部分患者在退热时会出现潜在的危及生命的并发症，包括血浆渗漏，偶尔会导致休克、出血和器官损害。由于登革热可能表现为发热、头痛和肌痛等非特异性症状，缺乏该疾病经验的医务人员存在误诊和管理不当的可能性，这令人担忧。本简短综述将概述世界卫生组织最新的疾病分类、潜在并发症、临床评估以及为在非流行地区工作的临床医生提供管理建议。
