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The case for conducting a randomized clinical trial to assess the efficacy of a single dose of prophylactic HPV vaccines among adolescents.开展一项随机临床试验以评估单剂量预防性人乳头瘤病毒（HPV）疫苗对青少年疗效的理由。
J Natl Cancer Inst. 2015 Feb 2;107(3). doi: 10.1093/jnci/dju436. Print 2015 Mar.
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Efficacy of fewer than three doses of an HPV-16/18 AS04-adjuvanted vaccine: combined analysis of data from the Costa Rica Vaccine and PATRICIA Trials.少于三剂HPV-16/18 AS04佐剂疫苗的效力：哥斯达黎加疫苗试验和PATRICIA试验数据的联合分析
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本文引用的文献

1
Sustained efficacy, immunogenicity, and safety of the HPV-16/18 AS04-adjuvanted vaccine: final analysis of a long-term follow-up study up to 9.4 years post-vaccination.人乳头瘤病毒16/18型AS04佐剂疫苗的持续疗效、免疫原性及安全性：接种疫苗后长达9.4年的长期随访研究最终分析
Hum Vaccin Immunother. 2014;10(8):2147-62. doi: 10.4161/hv.29532.
2
Immunogenicity of bivalent HPV vaccine among partially vaccinated young adolescent girls in Uganda.乌干达部分接种的年轻少女中二价人乳头瘤病毒疫苗的免疫原性
Vaccine. 2014 Oct 29;32(47):6303-11. doi: 10.1016/j.vaccine.2014.08.071. Epub 2014 Sep 16.
3
Long-term study of a quadrivalent human papillomavirus vaccine.四价人乳头瘤病毒疫苗的长期研究。
Pediatrics. 2014 Sep;134(3):e657-65. doi: 10.1542/peds.2013-4144. Epub 2014 Aug 18.
4
Human papillomavirus-16/18 AS04-adjuvanted vaccine (cervarix®): a guide to its two-dose schedule in girls aged 9-14 years in the EU.人乳头瘤病毒16/18型AS04佐剂疫苗（希瑞适®）：欧盟9至14岁女孩两剂次接种程序指南
Paediatr Drugs. 2014 Jun;16(3):247-53. doi: 10.1007/s40272-014-0071-7.
5
Effectiveness of quadrivalent human papillomavirus vaccine for the prevention of cervical abnormalities: case-control study nested within a population based screening programme in Australia.四价人乳头瘤病毒疫苗预防宫颈异常的效果：澳大利亚基于人群的筛查项目中嵌套的病例对照研究。
BMJ. 2014 Mar 4;348:g1458. doi: 10.1136/bmj.g1458.
6
Association of varying number of doses of quadrivalent human papillomavirus vaccine with incidence of condyloma.不同剂次四价人乳头瘤病毒疫苗接种与尖锐湿疣发病的关联。
JAMA. 2014 Feb 12;311(6):597-603. doi: 10.1001/jama.2014.95.
7
Durable antibody responses following one dose of the bivalent human papillomavirus L1 virus-like particle vaccine in the Costa Rica Vaccine Trial.在哥斯达黎加疫苗试验中，一剂二价人乳头瘤病毒 L1 病毒样颗粒疫苗可产生持久的抗体应答。
Cancer Prev Res (Phila). 2013 Nov;6(11):1242-50. doi: 10.1158/1940-6207.CAPR-13-0203.
8
Impact of a population-based HPV vaccination program on cervical abnormalities: a data linkage study.基于人群的 HPV 疫苗接种计划对宫颈异常的影响：一项数据关联研究。
BMC Med. 2013 Oct 22;11:227. doi: 10.1186/1741-7015-11-227.
9
Human papillomavirus vaccination coverage among adolescent girls, 2007-2012, and postlicensure vaccine safety monitoring, 2006-2013 - United States.2007-2012 年美国少女接种人乳头瘤病毒疫苗的情况，以及 2006-2013 年疫苗上市后的安全性监测。
MMWR Morb Mortal Wkly Rep. 2013 Jul 26;62(29):591-5.
10
Immunogenicity of 2 doses of HPV vaccine in younger adolescents vs 3 doses in young women: a randomized clinical trial.两剂 HPV 疫苗在青少年中的免疫原性与三剂 HPV 疫苗在年轻女性中的免疫原性比较：一项随机临床试验。
JAMA. 2013 May 1;309(17):1793-802. doi: 10.1001/jama.2013.1625.

The case for conducting a randomized clinical trial to assess the efficacy of a single dose of prophylactic HPV vaccines among adolescents.

作者信息

Kreimer Aimée R, Sherman Mark E, Sahasrabuddhe Vikrant V, Safaeian Mahboobeh

机构信息

Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch (ARK, MS), Division of Cancer Prevention, Breast and Gynecologic Cancer Research Group (MES, VVS), Division of Cancer Epidemiology and Genetics, Human Genetics Program (MES), and Division of Cancer Epidemiology and Genetics, Hormonal and Reproductive Epidemiology Branch (VVS), National Cancer Institute, National Institutes of Health, Bethesda, MD; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN (VVS).

出版信息

J Natl Cancer Inst. 2015 Feb 2;107(3). doi: 10.1093/jnci/dju436. Print 2015 Mar.

DOI:10.1093/jnci/dju436
PMID:25650316
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4326307/
Abstract
摘要