Prosomes discriminate between mRNA of adenovirus-infected and uninfected HeLa cells.
作者信息
Horsch A, Martins de Sa C, Dineva B, Spindler E, Schmid H P
机构信息
Biologisches Institut, Universität Stuttgart, FRG.
出版信息
FEBS Lett. 1989 Mar 27;246(1-2):131-6. doi: 10.1016/0014-5793(89)80268-6.
PMID:2565252
Abstract
Prosomes are small cytoplasmic RNP complexes associated with repressed mRNA. In in vitro translation, they discriminate between the mRNA of adenovirus-infected HeLa cells and those of uninfected cells grown under normal conditions. Prosomes as well as their RNA constituents interact much more strongly with poly(A)+ mRNA of infected cells and inhibit their translation in vitro preferentially. A possible role of prosomes in the differential regulation of translation is discussed.
摘要
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