Wu Haibo, Lu Rufeng, Peng Xiaorong, Xu Lihua, Cheng Linfang, Lu Xiangyun, Jin Changzhong, Xie Tiansheng, Yao Hangping, Wu Nanping
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Department of Emergency, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, China.
Infect Genet Evol. 2015 Apr;31:64-7. doi: 10.1016/j.meegid.2015.01.019. Epub 2015 Jan 31.
We characterized two novel highly pathogenic H5N6 influenza viruses isolated from Chinese poultry in 2013. Genomic analysis showed that both isolates were reassortants, and derived their genes from H5 and H6 subtype viruses found in poultry in China. The virulence of the two isolates was examined in chickens and mice, and both isolates were found to be highly pathogenic in chickens and only moderately virulent for mice. Our results show that continued circulation of these viruses could endanger both avian species and humans.
我们对2013年从中国家禽中分离出的两种新型高致病性H5N6流感病毒进行了特征分析。基因组分析表明，这两种分离株都是重配体，其基因来源于在中国家禽中发现的H5和H6亚型病毒。在鸡和小鼠中检测了这两种分离株的毒力，发现这两种分离株对鸡具有高致病性，而对小鼠仅具有中等毒力。我们的结果表明，这些病毒的持续传播可能会危及禽类和人类。
