Manaia Eloísa Berbel, Kaminski Renata Cristina Kiatkoski, de Oliveira Anselmo Gomes, Corrêa Marcos Antonio, Chiavacci Leila Aparecida
Drugs and Medicines Department, Faculty of Pharmaceutical Sciences, São Paulo State University - UNESP, Araraquara, Brazil.
Physical-Chemistry Department, Chemistry Institute, São Paulo State University - UNESP, Araraquara, Brazil.
Int J Nanomedicine. 2015 Jan 22;10:811-9. doi: 10.2147/IJN.S71980. eCollection 2015.
Multifunctional products have been developed to combine the benefits of functional components and terpinen-4-ol (TP) delivery systems. In this way, p-toluene sulfonic acid modified titanium dioxide (TiO2) nanoparticles and TP, an antioxidant, have been incorporated in liquid-crystalline formulations for photoprotection and controlled release of the TP, respectively. By X-ray powder diffraction and diffuse reflectance spectroscopy, we noted that using p-toluene sulfonic acid as a surface modifier made it possible to obtain smaller and more transparent TiO2 nanoparticles than those commercially available. The liquid-crystalline formulation containing the inorganic ultraviolet filter was classified as broad-spectrum performance by the absorbance spectroscopy measurements. The formulations containing modified TiO2 nanoparticles and TP were determined to be in the hexagonal phase by polarized light microscopy and small-angle X-ray scattering, which makes possible the controlled released of TP following zero-order kinetics. The developed formulations can control the release of TP. Constant concentrations of the substance have been released per time unit, and the modified TiO2 nanoparticles can act as a transparent inorganic sunscreen.
多功能产品已被开发出来，以结合功能成分和萜品-4-醇（TP）递送系统的优点。通过这种方式，对甲苯磺酸改性的二氧化钛（TiO₂）纳米颗粒和抗氧化剂TP已分别被纳入液晶制剂中，用于光保护和TP的控释。通过X射线粉末衍射和漫反射光谱，我们注意到使用对甲苯磺酸作为表面改性剂能够获得比市售产品更小且更透明的TiO₂纳米颗粒。通过吸光光谱测量，含有无机紫外线过滤器的液晶制剂被归类为具有广谱性能。通过偏光显微镜和小角X射线散射确定，含有改性TiO₂纳米颗粒和TP的制剂处于六方相，这使得TP能够按照零级动力学进行控释。所开发的制剂能够控制TP的释放。每单位时间释放恒定浓度的该物质，并且改性TiO₂纳米颗粒可以用作透明无机防晒剂。
