Centre for Clinical Research Sörmland, Uppsala University, Eskilstuna, Sweden.
Center for Clinical Research, Västmanlands County Hospital, Västerås, Sweden.
Breast Cancer (Dove Med Press). 2015 Jan 16;7:21-35. doi: 10.2147/BCTT.S47227. eCollection 2015.
As the number of long-term breast cancer survivors has increased, the side effects of adjuvant cancer therapy, such as cardiac toxicity, remain clinically important. Although the cardiac toxicity due to anthracyclines, radiotherapy, or trastuzumab is well-documented, several issues need to be clarified and are the subjects of extensive ongoing clinical research. This review summarizes the incidence of cardiac toxicity due to breast cancer adjuvant therapy and highlights the current trends in early detection and management of cardiac toxicities.
随着长期乳腺癌幸存者人数的增加，辅助癌症治疗的副作用，如心脏毒性，仍然具有重要的临床意义。尽管蒽环类药物、放疗或曲妥珠单抗引起的心脏毒性已有充分的记载，但仍有几个问题需要澄清，这些问题也是正在进行的广泛临床研究的主题。本文综述了乳腺癌辅助治疗引起的心脏毒性的发生率，并强调了心脏毒性的早期检测和管理的当前趋势。
