肝素在着床和胎盘形成中的生理和治疗作用。
The physiologic and therapeutic role of heparin in implantation and placentation.
机构信息
Department of Obstetrics and Gynecology, Azienda Ospedaliera Universitaria Integrata, Università degli Studi di Verona , Verona , Italy.
Department of Obstetrics and Gynecology, Soroka University Medical Center, School of Medicine, Ben Gurion University of the Negev , Beer Sheva , Israel.
出版信息
PeerJ. 2015 Jan 6;3:e691. doi: 10.7717/peerj.691. eCollection 2015.
Abstract
Implantation, trophoblast development and placentation are crucial processes in the establishment and development of normal pregnancy. Abnormalities of these processes can lead to pregnancy complications known as the great obstetrical syndromes: preeclampsia, intrauterine growth restriction, fetal demise, premature prelabor rupture of membranes, preterm labor, and recurrent pregnancy loss. There is mounting evidence regarding the physiological and therapeutic role of heparins in the establishment of normal gestation and as a modality for treatment and prevention of pregnancy complications. In this review, we will summarize the properties and the physiological contributions of heparins to the success of implantation, placentation and normal pregnancy.
摘要
胚胎着床、滋养层发育和胎盘形成是正常妊娠建立和发展的关键过程。这些过程的异常可导致妊娠并发症，即所谓的产科大症候群：子痫前期、宫内生长受限、胎儿死亡、早产胎膜早破、早产和反复妊娠丢失。肝素在正常妊娠中的生理和治疗作用以及作为治疗和预防妊娠并发症的一种方法的证据越来越多。在这篇综述中，我们将总结肝素的特性及其对胚胎着床、胎盘形成和正常妊娠成功的生理贡献。
相似文献
1
The physiologic and therapeutic role of heparin in implantation and placentation.
PeerJ. 2015 Jan 6;3:e691. doi: 10.7717/peerj.691. eCollection 2015.
2
The physiologic anticoagulant and anti-inflammatory role of heparins and their utility in the prevention of pregnancy complications.
Thromb Haemost. 2015 Jun;113(6):1236-46. doi: 10.1160/TH14-10-0848. Epub 2015 Apr 9.
3
Placental bed research: I. The placental bed: from spiral arteries remodeling to the great obstetrical syndromes.
Am J Obstet Gynecol. 2019 Nov;221(5):437-456. doi: 10.1016/j.ajog.2019.05.044. Epub 2019 Jun 1.
4
Defective implantation and placentation: laying the blueprint for pregnancy complications.
Reprod Biomed Online. 2007;14 Spec No 1:101-9. doi: 10.1016/S1472-6483(10)61464-2.
5
Defective implantation and placentation: laying the blueprint for pregnancy complications.
Reprod Biomed Online. 2006 Oct;13(4):591-9. doi: 10.1016/s1472-6483(10)60649-9.
6
Decreased expression of heparin-binding epidermal growth factor-like growth factor as a newly identified pathogenic mechanism of antiphospholipid-mediated defective placentation.
Arthritis Rheum. 2010 May;62(5):1504-12. doi: 10.1002/art.27361.
7
Failure of physiologic transformation of spiral arteries, endothelial and trophoblast cell activation, and acute atherosis in the basal plate of the placenta.
Am J Obstet Gynecol. 2017 Mar;216(3):287.e1-287.e16. doi: 10.1016/j.ajog.2016.12.029. Epub 2016 Dec 27.
8
The role of aspirin, heparin, and other interventions in the prevention and treatment of fetal growth restriction.
Am J Obstet Gynecol. 2018 Feb;218(2S):S829-S840. doi: 10.1016/j.ajog.2017.11.565. Epub 2017 Dec 8.
9
Placental vascular pathology and increased thrombin generation as mechanisms of disease in obstetrical syndromes.
PeerJ. 2014 Nov 18;2:e653. doi: 10.7717/peerj.653. eCollection 2014.
10
Placental bed research: II. Functional and immunological investigations of the placental bed.
Am J Obstet Gynecol. 2019 Nov;221(5):457-469. doi: 10.1016/j.ajog.2019.07.010. Epub 2019 Jul 6.
引用本文的文献
1
Low-molecular-weight heparin in the prevention of unexplained recurrent miscarriage: a systematic review and meta-analysis.
Sci Rep. 2024 Jun 19;14(1):14168. doi: 10.1038/s41598-024-62949-5.
2
Pregnancy and thrombosis risk for women without a history of thrombotic events: a retrospective study of the real risks.
Thromb J. 2022 Oct 6;20(1):60. doi: 10.1186/s12959-022-00419-6.
3
Association of the PECAM-1 (Leu125Val) and P-Selectin (Thr715Pro) Gene Polymorphisms With Unexplained Spontaneous Miscarriages.
Cureus. 2022 Feb 3;14(2):e21859. doi: 10.7759/cureus.21859. eCollection 2022 Feb.
4
-Segregation of c.1171C>T Stop Codon (p.R391*) in Gene and c.1691G>A Transition (p.R506Q) in Gene and Selected GWAS Multilocus Approach in Inherited Thrombophilia.
Genes (Basel). 2021 Jun 18;12(6):934. doi: 10.3390/genes12060934.
5
A Novel C1-Esterase Inhibitor Oxygenator Coating Prevents FXII Activation in Human Blood.
Biomolecules. 2020 Jul 13;10(7):1042. doi: 10.3390/biom10071042.
6
Low molecular weight heparins use in pregnancy: a practice survey from Greece and a review of the literature.
Thromb J. 2019 Dec 4;17:23. doi: 10.1186/s12959-019-0213-9. eCollection 2019.
7
Trophoblast-Derived CXCL16 Decreased Granzyme B Production of Decidual γδ T Cells and Promoted Bcl-xL Expression of Trophoblasts.
Reprod Sci. 2019 Apr;26(4):532-542. doi: 10.1177/1933719118777638. Epub 2018 Jun 18.
8
Systemic administration of heparin ameliorates radiation-induced oral mucositis-preclinical studies in mice.
Strahlenther Onkol. 2018 Jul;194(7):686-692. doi: 10.1007/s00066-018-1300-8. Epub 2018 Apr 16.
9
Antiangiogenic effects of decorin restored by unfractionated, low molecular weight, and nonanticoagulant heparins.
Blood Adv. 2017 Jul 3;1(16):1243-1253. doi: 10.1182/bloodadvances.2017004333. eCollection 2017 Jul 11.
10
Heparin-Mimicking Polymers: Synthesis and Biological Applications.
Biomacromolecules. 2016 Nov 14;17(11):3417-3440. doi: 10.1021/acs.biomac.6b01147. Epub 2016 Oct 14.
本文引用的文献
1
Synthesis of the heparin-based anticoagulant drug fondaparinux.
Angew Chem Int Ed Engl. 2014 Sep 8;53(37):9876-9. doi: 10.1002/anie.201404154. Epub 2014 Jul 15.
2
Endocrine basis for recurrent pregnancy loss.
Obstet Gynecol Clin North Am. 2014 Mar;41(1):103-12. doi: 10.1016/j.ogc.2013.10.003. Epub 2013 Dec 5.
3
Uterine factors.
Obstet Gynecol Clin North Am. 2014 Mar;41(1):57-86. doi: 10.1016/j.ogc.2013.10.002.
4
Thrombophilic mutations and polymorphisms, alone or in combination, and recurrent spontaneous abortion.
Clin Appl Thromb Hemost. 2015 May;21(4):365-72. doi: 10.1177/1076029613520465. Epub 2014 Jan 24.
5
Adjunct low-molecular-weight heparin to improve live birth rate after recurrent implantation failure: a systematic review and meta-analysis.
Hum Reprod Update. 2013 Nov-Dec;19(6):674-84. doi: 10.1093/humupd/dmt032. Epub 2013 Aug 2.
6
Low molecular weight heparin relieves experimental colitis in mice by downregulating IL-1β and inhibiting syndecan-1 shedding in the intestinal mucosa.
PLoS One. 2013 Jul 18;8(7):e66397. doi: 10.1371/journal.pone.0066397. Print 2013.
7
Unfractionated heparin ameliorates lipopolysaccharide-induced lung inflammation by downregulating nuclear factor-κB signaling pathway.
Inflammation. 2013 Dec;36(6):1201-8. doi: 10.1007/s10753-013-9656-5.
8
Management of women with recurrent pregnancy losses and antiphospholipid antibody syndrome.
Am J Reprod Immunol. 2013 Jun;69(6):596-607. doi: 10.1111/aji.12114. Epub 2013 Mar 25.
9
Mechanisms of implantation: strategies for successful pregnancy.
Nat Med. 2012 Dec;18(12):1754-67. doi: 10.1038/nm.3012.
10
Emerging nonanticoagulant role of low molecular weight heparins on extravillous trophoblast functions and on heparin binding-epidermal growth factor and cystein-rich angiogenic inducer 61 expression.
Fertil Steril. 2012 Oct;98(4):1028-36.e1-2. doi: 10.1016/j.fertnstert.2012.06.042. Epub 2012 Jul 19.
Zotero 插件