Mastrolia Salvatore Andrea, Mazor Moshe, Holcberg Gershon, Leron Elad, Beharier Ofer, Loverro Giuseppe, Erez Offer
Offer Erez, MD, Acting Director of the Maternal Fetal Medicine Unit, Department of Obstetrics and Gynecology, Soroka University Medical Center, School of Medicine, Faculty of Health Sciences, Ben Gurion University of the Negev, P. O. Box 151, Beer Sheva 84101, Israel, E-mail:
Thromb Haemost. 2015 Jun;113(6):1236-46. doi: 10.1160/TH14-10-0848. Epub 2015 Apr 9.
Accumulating evidence supports the concept of increased thrombin generation, placental vascular lesions, and inflammation as crucial points in the development of the great obstetrical syndromes [preeclampsia, intrauterine growth restriction (IUGR), preterm labor (PTL), preterm prelabor rupture of membranes (PROM), fetal demise and recurrent abortions]. In light of this, the role of heparins for primary or secondary prevention of these syndromes is becoming more and more apparent, mainly due to the antithrombotic and anti-inflammatory effects of heparins. There is agreement regarding the use of heparin in the prevention of gestational complications in patients with antiphospholipid syndrome, while its use for other obstetrical complications is under debate. In the present review we will describe the physiologic role of heparins on coagulation and inflammation and we will discuss current evidence regarding the use of heparins for the prevention/treatment of obstetrical syndromes.
越来越多的证据支持这样一种概念，即凝血酶生成增加、胎盘血管病变和炎症是导致严重产科综合征（子痫前期、胎儿生长受限、早产、胎膜早破、胎儿死亡和复发性流产）的关键点。鉴于此，肝素在这些综合征的一级或二级预防中的作用越来越明显，这主要归功于肝素的抗血栓形成和抗炎作用。对于肝素在抗磷脂综合征患者预防妊娠并发症中的应用已达成共识，而其在其他产科并发症中的应用仍存在争议。在本综述中，我们将描述肝素在凝血和炎症方面的生理作用，并讨论目前关于肝素用于预防/治疗产科综合征的证据。
