Muschiol Jan, Peters Christin, Oberleitner Nikolin, Mihovilovic Marko D, Bornscheuer Uwe T, Rudroff Florian
Institute of Biochemistry, Dept. of Biotechnology & Enzyme Catalysis, Greifswald University, Felix-Hausdorff-Str. 4, 17489 Greifswald, Germany.
Chem Commun (Camb). 2015 Apr 7;51(27):5798-811. doi: 10.1039/c4cc08752f. Epub 2015 Feb 5.
Nature's smartness and efficient assembling cascade type reactions inspired biologists and chemists all around the world. Tremendous effort has been directed towards the understanding and mimicking of such networks. In recent years considerable progress has been made in developing multistep one-pot reactions combining either advantage of chemo-, regio-, and stereoselectivity of biocatalysts or promiscuity and productivity of chemocatalysts. In this context several concepts, inspired by different disciplines (biocatalysis, metabolic engineering, synthetic chemistry, and material science), have been evolved. This review will focus on major contributions in the field of cascade reactions over the last three years.
自然界的智能且高效的组装级联型反应启发了世界各地的生物学家和化学家。人们付出了巨大努力来理解和模仿此类网络。近年来，在开发多步一锅法反应方面取得了显著进展，该反应结合了生物催化剂的化学、区域和立体选择性优势或化学催化剂的多用途性和高生产率。在此背景下，受不同学科（生物催化、代谢工程、合成化学和材料科学）启发的几个概念应运而生。本综述将聚焦过去三年中级联反应领域的主要贡献。
