Hübbers Christian U, Akgül Baki
a Jean-Uhrmacher-Institute for Otorhinolaryngological Research; University of Cologne ; Cologne , Germany.
Virulence. 2015;6(3):244-8. doi: 10.1080/21505594.2014.999570.
Increased awareness of human papillomavirus (HPV) as an etiological cause of head and neck squamous cell carcinoma has increased the interest in analysis of distinct oral sub-sites. It is currently under debate, whether HPV plays a role in the development of squamous cell carcinoma of the oral cavity (OSCC). The weakness in most published studies is the lack of performing different HPV detection tests combined with analysis for biological activity of the virus. In addition, different sub-sites of the oral cavity had been combined to a single entity, which retrospectively leads to a highly heterogeneous basis of data. In this review we mainly discuss the unclear role of HPV in OSCC development.
人乳头瘤病毒（HPV）作为头颈部鳞状细胞癌的病因，其认知度的提高增加了对不同口腔亚部位分析的兴趣。目前，HPV是否在口腔鳞状细胞癌（OSCC）的发生发展中起作用仍存在争议。大多数已发表研究的不足之处在于缺乏结合病毒生物学活性分析进行不同的HPV检测。此外，口腔的不同亚部位被合并为一个单一实体，这在回顾性研究中导致了数据基础高度异质性。在本综述中，我们主要讨论HPV在OSCC发生发展中尚不明确的作用。
