The University of Texas Health Science Center at Houston, 7000 Fannin St., UCT 2610C, Houston, TX 77030, USA.
Cancer Prev Res (Phila). 2013 Sep;6(9):917-24. doi: 10.1158/1940-6207.CAPR-13-0081. Epub 2013 Aug 21.
Oral human papillomavirus (HPV) infection is the cause of 40% to 80% of oropharyngeal cancers; yet, no published study has examined the role of oral health in oral HPV infection, either independently or in conjunction with other risk factors. This study examined the relation between oral health and oral HPV infection and the interactive effects of oral health, smoking, and oral sex on oral HPV infection. Our analyses comprised 3,439 participants ages 30 to 69 years for whom data on oral HPV and oral health were available from the nationally representative 2009-2010 National Health and Nutrition Examination Survey. Results showed that higher unadjusted prevalence of oral HPV infection was associated with four measures of oral health, including self-rated oral health as poor-to-fair [prevalence ratio (PR) = 1.56; 95% confidence interval (CI), 1.25-1.95], indicated the possibility of gum disease (PR = 1.51; 95% CI, 1.13-2.01), reported use of mouthwash to treat dental problems in the past week (PR = 1.28; 95% CI, 1.07-1.52), and higher number of teeth lost (Ptrend = 0.035). In multivariable logistic regression models, oral HPV infection had a statistically significant association with self-rated overall oral health (OR = 1.55; 95% CI, 1.15-2.09), independent of smoking and oral sex. In conclusion, poor oral health was an independent risk factor of oral HPV infection, irrespective of smoking and oral sex practices. Public health interventions may aim to promote oral hygiene and oral health as an additional measure to prevent HPV-related oral cancers.
口腔人乳头瘤病毒（HPV）感染是导致 40%至 80%口咽癌的原因；然而，目前还没有研究探讨口腔健康在口腔 HPV 感染中的作用，无论是独立作用还是与其他危险因素共同作用。本研究旨在探讨口腔健康与口腔 HPV 感染之间的关系，以及口腔健康、吸烟和口交对口腔 HPV 感染的交互作用。我们的分析包括了 3439 名年龄在 30 至 69 岁之间的参与者，他们来自于具有全国代表性的 2009-2010 年全国健康与营养调查（NHANES），这些参与者的数据包含了口腔 HPV 和口腔健康状况。结果显示，未经调整的口腔 HPV 感染率较高与口腔健康的四个指标有关，包括自我评估的口腔健康状况为差到一般（比值比 [PR] = 1.56；95%置信区间 [CI]，1.25-1.95）、表示可能患有牙龈疾病（PR = 1.51；95% CI，1.13-2.01）、报告在过去一周内使用漱口水治疗牙齿问题（PR = 1.28；95% CI，1.07-1.52）和牙齿缺失较多（P 趋势=0.035）。在多变量逻辑回归模型中，口腔 HPV 感染与自我评估的整体口腔健康状况（OR = 1.55；95% CI，1.15-2.09）有统计学显著关联，而与吸烟和口交无关。总之，口腔健康状况差是口腔 HPV 感染的一个独立危险因素，无论是否存在吸烟和口交行为。公共卫生干预措施可能旨在促进口腔卫生和口腔健康，作为预防 HPV 相关口咽癌的额外措施。
