Deretic Vojo, Kimura Tomonori, Timmins Graham, Moseley Pope, Chauhan Santosh, Mandell Michael
J Clin Invest. 2015 Jan;125(1):75-84. doi: 10.1172/JCI73945. Epub 2015 Jan 2.
The broad immunologic roles of autophagy span innate and adaptive immunity and are often manifested in inflammatory diseases. The immune effects of autophagy partially overlap with its roles in metabolism and cytoplasmic quality control but typically expand further afield to encompass unique immunologic adaptations. One of the best-appreciated manifestations of autophagy is protection against microbial invasion, but this is by no means limited to direct elimination of intracellular pathogens and includes a stratified array of nearly all principal immunologic processes. This Review summarizes the broad immunologic roles of autophagy. Furthermore, it uses the autophagic control of Mycobacterium tuberculosis as a paradigm to illustrate the breadth and complexity of the immune effects of autophagy.
自噬广泛的免疫作用涵盖先天性免疫和适应性免疫，且常表现在炎症性疾病中。自噬的免疫效应部分与其在代谢和细胞质质量控制中的作用重叠，但通常会进一步扩展到独特的免疫适应性方面。自噬最广为人知的表现之一是抵御微生物入侵，但这绝不仅限于直接清除细胞内病原体，还包括几乎所有主要免疫过程的分层排列。本综述总结了自噬广泛的免疫作用。此外，它以结核分枝杆菌的自噬控制为例，来说明自噬免疫效应的广度和复杂性。
