State Key Laboratory of Rare Earth Resource Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Changchun, 130022, China; Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, 130022, China.
Adv Mater. 2015 Feb 11;27(6):1097-104. doi: 10.1002/adma.201405105. Epub 2014 Dec 8.
Bifunctionalized mesoporous silica-supported gold nanoparticles as oxidase and peroxidase mimics for antibacterial applications are demonstrated. For the first time, these mesoporous silica-supported gold nanoparticles are applied as oxidase and peroxidase mimics. Taking advantage of their prominent enzyme activities, the MSN-AuNPs show excellent antibacterial properties against both Gram-negative and Gram-positive bacteria. Furthermore, MSN-AuNPs also exhibit outstanding performance in biofilm elimination .
本文首次将介孔硅负载金纳米粒子用作氧化酶和过氧化物酶的模拟物。利用其显著的酶活性，MSN-AuNPs 对革兰氏阴性菌和革兰氏阳性菌均表现出优异的抗菌性能。此外，MSN-AuNPs 在生物膜消除方面也表现出卓越的性能。
