Key Laboratory for Molecular Enzymology and Engineering, Ministry of Education, School of Life Sciences, Jilin University, Changchun, Jilin, 130012, China.
Anal Bioanal Chem. 2024 Nov;416(27):5915-5932. doi: 10.1007/s00216-024-05334-5. Epub 2024 May 15.
Recently, gold nanomaterials have been rapidly developed owing to their high stability, good biocompatibility, and multifunctionality. The unique catalytic activity of gold nanomaterials has driven the emergence of the concept for a "gold nanozyme." Understanding the characteristics of gold nanozymes is crucial for improving their catalytic performance as well as expanding their applications. In this review, we provide an overview of the intrinsic enzyme-like activities of gold nanozymes, including peroxidase-, catalase-, superoxide dismutase-, and glucose oxidase-like activities, and the catalytic mechanisms involved. In addition, strategies for modulating the catalytic activity of gold nanozymes and their applications in biosensing were discussed in detail. Moreover, we highlight the current challenges of gold nanozymes and look forward to attracting more attention for propelling the developments in this field.
近年来，由于金纳米材料具有高稳定性、良好的生物相容性和多功能性，因此得到了迅速发展。金纳米材料独特的催化活性催生了“纳米酶”这一概念。了解纳米酶的特性对于提高其催化性能以及拓展其应用至关重要。在这篇综述中，我们概述了金纳米酶的固有类酶活性，包括过氧化物酶、过氧化氢酶、超氧化物歧化酶和葡萄糖氧化酶样活性，以及相关的催化机制。此外，我们还详细讨论了调控金纳米酶催化活性的策略及其在生物传感中的应用。最后，我们强调了金纳米酶目前所面临的挑战，并期望吸引更多的关注，以推动该领域的发展。
