Jardim M R, Vital R, Hacker M A, Nascimento M, Balassiano S L, Sarno E N, Illarramendi X
Leprosy Laboratory, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, RJ, Brazil; Department of Neurology, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Leprosy Laboratory, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, RJ, Brazil; Department of Neurology, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Clin Neurol Neurosurg. 2015 Apr;131:5-10. doi: 10.1016/j.clineuro.2015.01.008. Epub 2015 Jan 12.
Leprosy causes nerve injury, which mimics clinical and neurophysiological conditions, rendering it an excellent model of peripheral neuropathy.
A retrospective study including 822 nerve conduction studies (NCS) of 509 patients was developed to appraise the electrophysiological pattern of leprosy neuropathy. NCS of motor and sensory nerves performed before, during, and after multidrug therapy (MDT) were analyzed.
During the three periods of MDT, while NCS alterations were similar regarding extension, topography, damage severity, and type of lesion, NCS showed that sensory was more frequent (sural nerve) (92-96%) than motor impairment (70-77%) (ulnar nerve).
Once axonal loss has been installed, nerve function is little affected by inflammatory, immune and/or bacterial events since chronic neuropathy has been established, inevitably leading to the well-known leprosy sequelae occurring at any time before and/or after leprosy diagnosis.
麻风病会导致神经损伤，其在临床和神经生理学方面与其他病症相似，使其成为周围神经病变的一个极佳模型。
开展了一项回顾性研究，纳入509例患者的822次神经传导研究（NCS），以评估麻风性神经病变的电生理模式。分析了多药联合治疗（MDT）前、治疗期间和治疗后的运动和感觉神经的NCS。
在MDT的三个阶段，虽然NCS改变在范围、部位、损伤严重程度和病变类型方面相似，但NCS显示感觉神经损伤（腓肠神经）（92 - 96%）比运动神经损伤（尺神经）（70 - 77%）更常见。
一旦轴突损失发生，由于慢性神经病变已经形成，神经功能受炎症、免疫和/或细菌事件的影响很小，这不可避免地导致在麻风病诊断之前和/或之后的任何时间出现众所周知的麻风病后遗症。
