Kiessling Maren C, Milz Stefan, Frank Hans-Georg, Korbel Rüdiger, Schmitz Christoph
Extracorporeal Shock Wave Research Unit, Department of Anatomy II, Ludwig-Maximilians-University of Munich, Munich, Germany.
Clinic for Birds, Reptiles, Amphibians and Pet Fish, Ludwig-Maximilians-University of Munich, Oberschleissheim, Germany.
Sci Rep. 2015 Feb 6;5:8281. doi: 10.1038/srep08281.
Radial extracorporeal shock wave treatment (rESWT) has became one of the best investigated treatment modalities for cellulite, including the abdomen as a treatment site. Notably, pregnancy is considered a contraindication for rESWT, and concerns have been raised about possible harm to the embryo when a woman treated with rESWT for cellulite is not aware of her pregnancy. Here we tested the hypothesis that rESWT may cause serious physical harm to embryos. To this end, chicken embryos were exposed in ovo to various doses of radial shock waves on either day 3 or day 4 of development, resembling the developmental stage of four- to six-week-old human embryos. We found a dose-dependent increase in the number of embryos that died after radial shock wave exposure on either day 3 or day 4 of development. Among the embryos that survived the shock wave exposure a few showed severe congenital defects such as missing eyes. Evidently, our data cannot directly be used to draw conclusions about potential harm to the embryo of a pregnant woman treated for cellulite with rESWT. However, to avoid any risks we strongly recommend applying radial shock waves in the treatment of cellulite only if a pregnancy is ruled out.
径向体外冲击波治疗（rESWT）已成为治疗橘皮组织（包括将腹部作为治疗部位）研究得最为充分的治疗方式之一。值得注意的是，怀孕被视为rESWT的禁忌症，当接受rESWT治疗橘皮组织的女性未意识到自己怀孕时，人们对胚胎可能受到的伤害表示担忧。在此，我们检验了rESWT可能对胚胎造成严重身体伤害这一假设。为此，在鸡胚胎发育的第3天或第4天，将其在卵内暴露于不同剂量的径向冲击波下，这类似于人类4至6周龄胚胎的发育阶段。我们发现，在发育的第3天或第4天接受径向冲击波暴露后死亡的胚胎数量呈剂量依赖性增加。在冲击波暴露后存活的胚胎中，有一些出现了严重的先天性缺陷，如眼睛缺失。显然，我们的数据不能直接用于得出关于接受rESWT治疗橘皮组织的孕妇胚胎潜在伤害的结论。然而，为避免任何风险，我们强烈建议仅在排除怀孕的情况下，才将径向冲击波应用于橘皮组织的治疗。
