Kasashima-Shindo Yuko, Fujiwara Toshiyuki, Ushiba Junichi, Matsushika Yayoi, Kamatani Daiki, Oto Misa, Ono Takashi, Nishimoto Atsuko, Shindo Keiichiro, Kawakami Michiyuki, Tsuji Tetsuya, Liu Meigen
Department of Rehabilitation Medicine, Keio University School of Medicine, 160-8582 Tokyo, Japan.
J Rehabil Med. 2015 Apr;47(4):318-24. doi: 10.2340/16501977-1925.
Brain-computer interface technology has been applied to stroke patients to improve their motor function. Event-related desynchronization during motor imagery, which is used as a brain-computer interface trigger, is sometimes difficult to detect in stroke patients. Anodal transcranial direct current stimulation (tDCS) is known to increase event-related desynchronization. This study investigated the adjunctive effect of anodal tDCS for brain-computer interface training in patients with severe hemiparesis.
Eighteen patients with chronic stroke.
A non-randomized controlled study.
Subjects were divided between a brain-computer interface group and a tDCS- brain-computer interface group and participated in a 10-day brain-computer interface training. Event-related desynchronization was detected in the affected hemisphere during motor imagery of the affected fingers. The tDCS-brain-computer interface group received anodal tDCS before brain-computer interface training. Event-related desynchronization was evaluated before and after the intervention. The Fugl-Meyer Assessment upper extremity motor score (FM-U) was assessed before, immediately after, and 3 months after, the intervention.
Event-related desynchronization was significantly increased in the tDCS- brain-computer interface group. The FM-U was significantly increased in both groups. The FM-U improvement was maintained at 3 months in the tDCS-brain-computer interface group.
Anodal tDCS can be a conditioning tool for brain-computer interface training in patients with severe hemiparetic stroke.
脑机接口技术已应用于中风患者以改善其运动功能。运动想象期间的事件相关去同步化被用作脑机接口触发因素，有时在中风患者中难以检测到。已知阳极性经颅直流电刺激（tDCS）可增加事件相关去同步化。本研究调查了阳极性tDCS对严重偏瘫患者脑机接口训练的辅助作用。
18例慢性中风患者。
非随机对照研究。
受试者被分为脑机接口组和tDCS-脑机接口组，并参加为期10天的脑机接口训练。在患侧手指运动想象期间，在患侧半球检测事件相关去同步化。tDCS-脑机接口组在脑机接口训练前接受阳极性tDCS。在干预前后评估事件相关去同步化。在干预前、干预后即刻以及干预后3个月评估Fugl-Meyer评估上肢运动评分（FM-U）。
tDCS-脑机接口组的事件相关去同步化显著增加。两组的FM-U均显著增加。tDCS-脑机接口组在3个月时FM-U的改善得以维持。
阳极性tDCS可作为严重偏瘫性中风患者脑机接口训练的一种调节工具。
