Li Kun, Zhu Min, Xu Peng, Xi Yanhai, Cheng Zisheng, Zhu Yufang, Ye Xiaojian
Department of Orthopedics, Changzheng Hospital of Second Military Medical University, No. 500 Nanjing West Road, Shanghai, 200003, People's Republic of China.
J Mater Sci Mater Med. 2015 Feb;26(2):102. doi: 10.1007/s10856-015-5455-x. Epub 2015 Feb 6.
A suitable drug-loaded scaffold that can postoperatively release an antituberculosis drug efficiently in a lesion area and help repair a bone defect is very important in the clinical treatment of bone tuberculosis (TB). In this study, a composite drug-loaded cylindrical scaffold was prepared by using three-dimensional printing technology in combination with the mesoporous confinement range, surface chemical groups, and gradual degradation of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate). This achieves the slow release of a drug for as long as possible. We implanted the drug-loaded compound scaffold into New Zealand rabbits' femur defect model to study the in vivo drug release performance and osteogenic ability. The in vivo release of isoniazid and rifampicin from the prepared composites could be effectively sustained for 12 weeks in local tissues, whereas these drugs were sustained for just 2 weeks in a control group. The blood drug concentrations were very low and most concentrations were below 5 μg/ml. Therefore, the systemic toxic adverse effect is very low. In addition, the composite exhibits good osteogenic potential in a rabbit bone defect model. The results of this study indicate that this composite has great potential for treating osteoarticular TB.
一种合适的载药支架，能够在术后于病灶区域有效释放抗结核药物并有助于修复骨缺损，这在骨结核的临床治疗中非常重要。在本研究中，结合三维打印技术以及聚（3-羟基丁酸酯-co-3-羟基己酸酯）的介孔限制范围、表面化学基团和逐步降解，制备了一种复合载药圆柱形支架。这实现了药物尽可能长时间的缓释。我们将载药复合支架植入新西兰兔股骨缺损模型中，以研究其体内药物释放性能和成骨能力。所制备的复合材料中异烟肼和利福平在局部组织中的体内释放可有效持续12周，而在对照组中这些药物仅持续2周。血药浓度非常低，大多数浓度低于5μg/ml。因此，全身毒性不良反应非常低。此外，该复合材料在兔骨缺损模型中表现出良好的成骨潜力。本研究结果表明，这种复合材料在治疗骨关节结核方面具有巨大潜力。
