The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, PR China; Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, PR China; Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, PR China.
Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, PR China.
Colloids Surf B Biointerfaces. 2014 Apr 1;116:72-80. doi: 10.1016/j.colsurfb.2013.12.052. Epub 2013 Dec 30.
Scaffolds play a critical role in bone tissue engineering. Composite scaffolds made of biodegradable polymers and bioactive inorganic compounds have demonstrated superior properties in bone defect repair. In this study, highly bioactive, resorbable poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx)-based scaffolds were prepared using combinational 3-dimensional (3D) printing and surface-doping protocol. Structural and morphological characterization of the composite scaffolds demonstrated the homogenous surface-coating of mesoporous bioactive glass (MBG) throughout their porous framework. These hierarchical scaffolds showed bioactivity superior to that of scaffolds made of pure PHBHHx. MBG coating appeared to provide a better environment for human mesenchymal stem cells (hMSCs) attachment, activity, and osteogenic differentiation. Our study indicates that MBG-coated PHBHHx (PHBM) scaffolds may be excellent candidates for use in bone tissue engineering.
支架在骨组织工程中起着关键作用。由可生物降解聚合物和生物活性无机化合物制成的复合支架在骨缺损修复中表现出优异的性能。在这项研究中，使用组合式 3D 打印和表面掺杂方案制备了高生物活性、可吸收的聚（3-羟基丁酸-co-3-羟基己酸）（PHBHHx）基支架。对复合支架的结构和形态特征的研究表明，介孔生物活性玻璃（MBG）均匀地涂覆在整个多孔支架的表面。这些分级支架的生物活性优于纯 PHBHHx 支架。MBG 涂层似乎为人间充质干细胞（hMSCs）的附着、活性和成骨分化提供了更好的环境。我们的研究表明，MBG 涂层的 PHBHHx（PHBM）支架可能是骨组织工程中非常有前途的候选材料。
