Li S J, Wong S C, Ingenito A J
Department of Pharmacology, School of Medicine, East Carolina University, Greenville, NC 27858-4354.
Neuropeptides. 1989 Apr;13(3):197-200. doi: 10.1016/0143-4179(89)90092-9.
Dynorphin A (1-8)-like immunoreactivity (DN-LI A(1-8] was determined by radioimmunoassay in the brains of age matched spontaneously hypertensive rats (SHR) and two normotensive control groups consisting of Wistar-Kyoto (WKY) and Sprague-Dawley (SD) strain rats. A significantly lower DN-LI A(1-8) was found in the hippocampus and hypothalamus of the SHR compared with the WKY groups. DN-LI A(1-8) was 24% of control WKY levels in hippocampus and 79% of that in WKY hypothalamus at 16 weeks. Similar lower levels of DN-LI A(1-8) were also observed in SHR at 4, 8, and 12 weeks during the development of hypertension when compared with both WKY and SD groups. We failed to find significant differences in brain stem DN levels between the groups. The relationship between the low hippocampal dynorphin levels in SHR and the hypertension is problematical because the differences were present before (4 wks), during (8 and 12 wks) and after (16 wks) its development.
采用放射免疫分析法测定了年龄匹配的自发性高血压大鼠（SHR）以及由Wistar-Kyoto（WKY）和Sprague-Dawley（SD）品系大鼠组成的两个正常血压对照组大鼠脑内强啡肽A（1-8）样免疫反应性（DN-LI A（1-8））。与WKY组相比，SHR海马和下丘脑的DN-LI A（1-8）显著降低。在16周时，海马中DN-LI A（1-8）为对照WKY组水平的24%，在下丘脑中为WKY组的79%。在高血压发展过程中的4周、8周和12周时，与WKY和SD组相比，SHR中也观察到类似的较低水平的DN-LI A（1-8）。我们未发现各组脑干DN水平存在显著差异。SHR海马中强啡肽水平低与高血压之间的关系存在问题，因为在高血压发生之前（4周）、期间（8周和12周）和之后（16周）均存在差异。
