Conway E L, Maccarrone C, Verberne A J, Louis W J
Clin Exp Hypertens A. 1987;9(1):109-24. doi: 10.3109/10641968709160033.
The concentration of dynorphin (1-8) immunoreactivity [ir-dyn(1-8)] was measured in 10 hypothalamic and 11 brainstem nuclei of Sprague-Dawley (SD) and 6- and 14-week old Wistar-Kyoto (WKY) and spontaneously hypertensive (SH) rats. The highest concentrations of ir-dyn(1-8) were found in the lateral preoptic and lateral hypothalamic areas of the hypothalamus and the solitary tract nucleus of the brainstem. Levels of the peptide were low in other brainstem nuclei compared to hypothalamic areas. There was a significant reduction in ir-dyn(1-8) concentrations at 14 weeks of age compared to 6 weeks of age in all 9 nuclei examined in SH and WKY rats. However, there were no differences between the strains at either age. These changes may be related to the increase in blood pressure that occurs in both SH and WKY rats over this age range although other factors must also be involved to produce the higher blood pressure levels of the SH rat.
在10个下丘脑核团和11个脑干核团中测量了斯普拉格-道利（SD）大鼠、6周龄和14周龄的Wistar-Kyoto（WKY）大鼠以及自发性高血压（SH）大鼠体内强啡肽（1-8）免疫反应性[ir-dyn(1-8)]的浓度。在下丘脑的视前外侧区和下丘脑外侧区以及脑干的孤束核中发现ir-dyn(1-8)的浓度最高。与下丘脑区域相比，其他脑干核团中的该肽水平较低。在SH和WKY大鼠检查的所有9个核团中，14周龄时ir-dyn(1-8)的浓度与6周龄时相比显著降低。然而，在这两个年龄段，不同品系之间均无差异。这些变化可能与SH和WKY大鼠在该年龄范围内血压升高有关，尽管还必须涉及其他因素才能使SH大鼠产生更高的血压水平。
