Danguir J, De Saint-Hilaire Kafi S
CNRS URA235 Neurbiologie des Régulations, Collège de France, Paris.
Neurosci Lett. 1989 Mar 27;98(2):154-8. doi: 10.1016/0304-3940(89)90502-8.
EEG sleep recordings were performed in rats under intraperitoneal injections of saline, desipramine (DMI, 4 mg/kg) an inhibitor of noradrenaline reuptake, and DMI plus the octapeptide somatostatin analogue (octreotide, 0.2 mg/kg). As already reported, DMI resulted in selective suppression of paradoxical sleep (PS) and increased slow wave sleep (SWS). The administration of the octapeptide somatostatin analogue totally reversed the DMI-induced suppression of PS, but had no effect on SWS. This finding confirms previous results demonstrating a role of somatostatin in the generation of PS. In addition, it suggests that the suppression of PS by DMI may be due to an inhibitory effect on somatostatin release, rather than to an alteration of brain noradrenaline.
在大鼠腹腔注射生理盐水、去甲丙咪嗪（DMI，4毫克/千克，一种去甲肾上腺素再摄取抑制剂）以及DMI加八肽生长抑素类似物（奥曲肽，0.2毫克/千克）的情况下进行脑电图睡眠记录。如先前报道，DMI导致异相睡眠（PS）选择性受抑制，慢波睡眠（SWS）增加。八肽生长抑素类似物的给药完全逆转了DMI诱导的PS抑制，但对SWS无影响。这一发现证实了先前的结果，表明生长抑素在PS产生中起作用。此外，这表明DMI对PS的抑制可能是由于对生长抑素释放的抑制作用，而非脑内去甲肾上腺素的改变。
