Danguir J, de Saint-Hilaire-Kafi S
Neurobiologie des Régulations, CNRS UA 637, Collège de France, Paris.
Pharmacol Biochem Behav. 1988 Jun;30(2):295-7. doi: 10.1016/0091-3057(88)90457-1.
The intraperitoneal administration of the octapeptide somatostatin analogue SMS 201-995 produced a significant increase in paradoxical sleep (PS) in rats. The suppression of PS by the muscarinic receptor blocker scopolamine was reversed by SMS 201-995. These findings confirm previous results demonstrating a role of somatostatin in the generation of PS. In addition they suggest that the suppression of PS by scopolamine may be due to an inhibitory effect on somatostatin release, rather than to an alteration of cholinergic function alone.
给大鼠腹腔注射八肽生长抑素类似物SMS 201-995后，其异相睡眠（PS）显著增加。毒蕈碱受体阻滞剂东莨菪碱对PS的抑制作用可被SMS 201-995逆转。这些发现证实了先前的结果，即生长抑素在PS产生中起作用。此外，这些结果还表明，东莨菪碱对PS的抑制作用可能是由于对生长抑素释放的抑制作用，而不仅仅是胆碱能功能的改变。
