Danguir J
CNRS UA 637, Neurobiologie des Régulations, Collége de France, Paris.
Neurobiol Aging. 1989 Jul-Aug;10(4):367-9. doi: 10.1016/0197-4580(89)90050-x.
Sleep patterns were recorded in aged rats (800- to 840-day-old) under control conditions and following either intraperitoneal injections of three different doses of the octapeptide somatostatin analogue SMS 201-995 (SMS) or after spontaneous oral intake of SMS-containing water (0.003 mg/ml). The intraperitoneal administration of SMS resulted in a dose-dependent and selective increase of paradoxical sleep (SP). Similarly, the spontaneous oral ingestion of SMS induced a significant increase of the daily duration of PS. Slow wave sleep remained unchanged in both cases. These findings confirm previous results demonstrating a role of somatostatin in the generation of PS. In addition, they suggest that sleep deficits during aging may be the consequence of decreased age-related somatostatin release.
在对照条件下，以及在老年大鼠（800至840日龄）腹腔注射三种不同剂量的八肽生长抑素类似物SMS 201-995（SMS）或自发口服含SMS的水（0.003毫克/毫升）之后，记录其睡眠模式。腹腔注射SMS导致异相睡眠（SP）呈剂量依赖性且选择性增加。同样，自发口服SMS引起每日PS时长显著增加。在这两种情况下，慢波睡眠均未改变。这些发现证实了先前的结果，即生长抑素在PS产生中起作用。此外，它们表明衰老过程中的睡眠缺陷可能是与年龄相关的生长抑素释放减少的结果。
